Clinical trial

Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial

NCT01369069

StatusCOMPLETED

Study typeINTERVENTIONAL

Start date2012-04-01

PhasePHASE3

Study timeline

Study start (actual)2012-04-01Date precision: month

Registry last updated2019-12-23

Observed by CureCurrent2026-10-07

Recorded dates are source observations, not predictions. Missing milestones are not estimated.

Conditions

Acute Ischemic Strokeunresolved

Diabetesunresolved

Hyperglycemiaunresolved

Interventions

IV insulin to maintain target glucose concentration of 80-130 mg/dLDRUG

Standard Care control - sliding scale insulin to keep glucose less than 180 mg/dLDRUG

Sponsors & collaborators

University of Virginialead sponsor

Neurological Emergencies Treatment Trials Network (NETT)collaborator

Medical University of South Carolinacollaborator

National Institute of Neurological Disorders and Stroke (NINDS)collaborator

Mapped research locations

New YorkNew York, United States4 San FranciscoCalifornia, United States4 PhiladelphiaPennsylvania, United States3 AtlantaGeorgia, United States3 PittsburghPennsylvania, United States3 DetroitMichigan, United States3 HoustonTexas, United States2 BostonMassachusetts, United States2 DallasTexas, United States2 NashvilleTennessee, United States2 MinneapolisMinnesota, United States2 AustinTexas, United States2

Registry source

Open the source record to verify current eligibility, contacts, locations and registry updates.

Open NCT01369069 on ClinicalTrials.gov ↗

Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.