Clinical trial
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)
NCT02465060
Study timeline
Study start (actual)2015-08-17Date precision: day
Registry last updated2026-10-01
Observed by CureCurrent2026-10-07
Recorded dates are source observations, not predictions. Missing milestones are not estimated.
Conditions
Advanced Lymphomaunresolved
Advanced Malignant Solid Neoplasmunresolved
Bladder Carcinomaunresolved
Breast Carcinomaunresolved
Cervical Carcinomaunresolved
Colon Carcinomaunresolved
Colorectal Carcinomaunresolved
Endometrial Carcinomaunresolved
Esophageal Carcinomaunresolved
Exocrine Pancreas Carcinomaunresolved
Gastric Carcinomaunresolved
Gliomaunresolved
Head and Neck Carcinomaunresolved
Hematopoietic and Lymphoid Cell Neoplasmunresolved
Kidney Carcinomaunresolved
Liver Carcinomaunresolved
Lung Carcinomaunresolved
Lymphomaunresolved
Malignant Uterine Corpus Neoplasmunresolved
Malignant Uterine Neoplasmunresolved
Melanomaunresolved
Multiple Myelomaunresolved
Ovarian Carcinomaunresolved
Prostate Carcinomaunresolved
Rectal Carcinomaunresolved
Recurrent Bladder Carcinomaunresolved
Recurrent Breast Carcinomaunresolved
Recurrent Cervical Carcinomaunresolved
Recurrent Colon Carcinomaunresolved
Recurrent Colorectal Carcinomaunresolved
Recurrent Esophageal Carcinomaunresolved
Recurrent Gastric Carcinomaunresolved
Recurrent Gliomaunresolved
Recurrent Head and Neck Carcinomaunresolved
Recurrent Liver Carcinomaunresolved
Recurrent Lung Carcinomaunresolved
Recurrent Lymphomaunresolved
Recurrent Malignant Solid Neoplasmunresolved
Recurrent Melanomaunresolved
Recurrent Multiple Myelomaunresolved
Recurrent Ovarian Carcinomaunresolved
Recurrent Pancreatic Carcinomaunresolved
Recurrent Prostate Carcinomaunresolved
Recurrent Rectal Carcinomaunresolved
Recurrent Skin Carcinomaunresolved
Recurrent Thyroid Gland Carcinomaunresolved
Refractory Lymphomaunresolved
Refractory Malignant Solid Neoplasmunresolved
Refractory Multiple Myelomaunresolved
Skin Carcinomaunresolved
Thyroid Gland Carcinomaunresolved
Interventions
AdavosertibDRUG
AfatinibDRUG · verified · RxNorm: afatinib
Afatinib DimaleateDRUG · verified · RxNorm: afatinib dimaleate
BinimetinibDRUG · verified · RxNorm: binimetinib
Biopsy ProcedurePROCEDURE
Biospecimen CollectionPROCEDURE
CapivasertibDRUG · verified · RxNorm: capivasertib
Computed TomographyPROCEDURE
CopanlisibDRUG · verified · RxNorm: copanlisib
CrizotinibDRUG · verified · RxNorm: crizotinib
DabrafenibDRUG · verified · RxNorm: dabrafenib
Dabrafenib MesylateDRUG · verified · RxNorm: dabrafenib mesylate
DasatinibDRUG · verified · RxNorm: dasatinib
DefactinibDRUG · verified · RxNorm: defactinib
Defactinib HydrochlorideDRUG · verified · RxNorm: defactinib hydrochloride
Echocardiography TestPROCEDURE
ErdafitinibDRUG · verified · RxNorm: erdafitinib
FexagratinibDRUG
IpatasertibDRUG
LarotrectinibDRUG · verified · RxNorm: larotrectinib
Magnetic Resonance ImagingPROCEDURE
Multigated Acquisition ScanPROCEDURE
NivolumabBIOLOGICAL
OsimertinibDRUG · verified · RxNorm: osimertinib
PalbociclibDRUG · verified · RxNorm: palbociclib
PertuzumabBIOLOGICAL
Radiologic ExaminationPROCEDURE
Radionuclide ImagingPROCEDURE
RelatlimabBIOLOGICAL
SapanisertibDRUG · verified · RxNorm: sapanisertib
Sunitinib MalateDRUG · verified · RxNorm: sunitinib malate
TaselisibDRUG
TrametinibDRUG · verified · RxNorm: trametinib
TrastuzumabBIOLOGICAL
Trastuzumab EmtansineBIOLOGICAL
UlixertinibDRUG
VismodegibDRUG · verified · RxNorm: vismodegib
Sponsors & collaborators
National Cancer Institute (NCI)lead sponsor
Mapped research locations
Las VegasNevada, United States33HonoluluHawaii, United States13DenverColorado, United States12Baton RougeLouisiana, United States12CincinnatiOhio, United States11OmahaNebraska, United States11SeattleWashington, United States9PittsburghPennsylvania, United States9ChicagoIllinois, United States8ColumbusOhio, United States8BaltimoreMaryland, United States7St LouisMissouri, United States7
Registry source
Open the source record to verify current eligibility, contacts, locations and registry updates.
Open NCT02465060 on ClinicalTrials.gov ↗Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.