Clinical trial
Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)
NCT03155620
Study timeline
Study start (actual)2017-07-31Date precision: day
Registry last updated2026-07-24
Observed by CureCurrent2026-10-07
Recorded dates are source observations, not predictions. Missing milestones are not estimated.
Conditions
Advanced Malignant Solid Neoplasmunresolved
Ann Arbor Stage III Non-Hodgkin Lymphomaunresolved
Ann Arbor Stage IV Non-Hodgkin Lymphomaunresolved
Histiocytic Sarcomaunresolved
Juvenile Xanthogranulomaunresolved
Langerhans Cell Histiocytosisunresolved
Malignant Gliomaunresolved
Recurrent Childhood Rhabdomyosarcomaunresolved
Recurrent Ependymomaunresolved
Recurrent Ewing Sarcomaunresolved
Recurrent Gliomaunresolved
Recurrent Hepatoblastomaunresolved
Recurrent Langerhans Cell Histiocytosisunresolved
Recurrent Malignant Germ Cell Tumorunresolved
Recurrent Malignant Solid Neoplasmunresolved
Recurrent Medulloblastomaunresolved
Recurrent Neuroblastomaunresolved
Recurrent Non-Hodgkin Lymphomaunresolved
Recurrent Osteosarcomaunresolved
Recurrent Rhabdoid Tumorunresolved
Recurrent Soft Tissue Sarcomaunresolved
Refractory Ewing Sarcomaunresolved
Refractory Gliomaunresolved
Refractory Hepatoblastomaunresolved
Refractory Langerhans Cell Histiocytosisunresolved
Refractory Malignant Germ Cell Tumorunresolved
Refractory Malignant Solid Neoplasmunresolved
Refractory Medulloblastomaunresolved
Refractory Neuroblastomaunresolved
Refractory Non-Hodgkin Lymphomaunresolved
Refractory Osteosarcomaunresolved
Refractory Rhabdoid Tumorunresolved
Refractory Rhabdomyosarcomaunresolved
Rhabdoid Tumorunresolved
Stage III Osteosarcoma AJCC v7unresolved
Stage III Soft Tissue Sarcoma AJCC v7unresolved
Stage IV Osteosarcoma AJCC v7unresolved
Stage IV Soft Tissue Sarcoma AJCC v7unresolved
Stage IVA Osteosarcoma AJCC v7unresolved
Stage IVB Osteosarcoma AJCC v7unresolved
Wilms Tumorunresolved
Interventions
Biopsy ProcedurePROCEDURE
Biospecimen CollectionPROCEDURE
Bone Marrow Aspiration and BiopsyPROCEDURE
Bone ScanPROCEDURE
Computed TomographyPROCEDURE
EnsartinibDRUG · verified · RxNorm: ensartinib
ErdafitinibDRUG · verified · RxNorm: erdafitinib
IvosidenibDRUG · verified · RxNorm: ivosidenib
Magnetic Resonance ImagingPROCEDURE
Mutation Carrier ScreeningPROCEDURE
OlaparibDRUG · verified · RxNorm: olaparib
PalbociclibDRUG · verified · RxNorm: palbociclib
Positron Emission TomographyPROCEDURE
Radionuclide ImagingPROCEDURE
SamotolisibDRUG
SelpercatinibDRUG · verified · RxNorm: selpercatinib
TazemetostatDRUG · verified · RxNorm: tazemetostat
TipifarnibDRUG
UlixertinibDRUG
VemurafenibDRUG · verified · RxNorm: vemurafenib
X-Ray ImagingPROCEDURE
Sponsors & collaborators
National Cancer Institute (NCI)lead sponsor
Mapped research locations
New YorkNew York, United States4Las VegasNevada, United States4ChicagoIllinois, United States3Los AngelesCalifornia, United States3BaltimoreMaryland, United States3St LouisMissouri, United States3San AntonioTexas, United States3OrlandoFlorida, United States3HoustonTexas, United States2BostonMassachusetts, United States2DallasTexas, United States2MiamiFlorida, United States2
Registry source
Open the source record to verify current eligibility, contacts, locations and registry updates.
Open NCT03155620 on ClinicalTrials.gov ↗Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.