Condition
Alzheimer Disease, Early Onset
ClinicalTrials.gov condition label
How to interpret these research links
Connected source recordsThis is the original ClinicalTrials.gov condition label, found in 57 distinct published trials. It is kept separate from a MONDO disease identifier until a specific normalization is supported. Related interventions are co-recorded in studies; they are not medical recommendations.
Data basis: current published ClinicalTrials.gov records and, where present, RxNorm, MONDO and FDA-label identifiers. See the evidence interpretation and counting methodology.
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Clinical trials
57 shownA Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL628 in Participants With Early Alzheimer's DiseaseNCT07328451 · 2026-01-30
RECRUITINGStudy of ARO-MAPT-SC in Healthy Participants and Participants With Early Alzheimer's DiseaseNCT07221344 · 2025-11-18
RECRUITINGTranscranial Magnetic Stimulation to Slow Down Cognitive Decline in Alzheimer's DiseaseNCT07036328 · 2025-04-07
RECRUITINGNeuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's DiseaseNCT06688968 · 2025-02-04
RECRUITINGA Multifocal tDCS-EEG Protocol for Improving Symptoms of Mild Cognitive Impairment and Early DementiaNCT06668610 · 2024-10-01
RECRUITINGMIMA Pilot Study: MIcrostructure of the Medial Temporal Lobe in Early Alzheimer's DiseaseNCT06099587 · 2024-07-02
RECRUITINGLifestyle Interventions for the Treatment of Early Onset Alzheimer's Disease StudyNCT05573490 · 2024-01-11
RECRUITINGNetwork-based biOmarker Discovery of Neurodegenerative Diseases Using Multimodal ConnectivityNCT06080659 · 2023-11-06
RECRUITINGChronic Treatment of Alzheimer's Disease by Gamma Light and Sound TherapyNCT05655195 · 2022-12-14
RECRUITINGNYSCF Scientific Discovery BiobankNCT06203106 · 2022-11-10
RECRUITINGThe Dampness Syndrome of Chinese Medicine Cohort StudyNCT05315895 · 2022-06-06
RECRUITINGDonepezil Versus Non-drug Treatment in Alzheimer's Disease.NCT04661280 · 2022-02-10
RECRUITINGMECHANISMS OF NEURONAL RESILIENCE IN ALZHEIMER'S DISEASE AND ITS FOCAL VARIANTS: A PET/MR STUDYNCT04150198 · 2021-12-08
RECRUITINGGnRH Therapy on Cognition in Down SyndromeNCT04390646 · 2020-08-27
RECRUITINGMolecular and Structural Imaging in Alzheimer's Disease: A Longitudinal StudyNCT02740634 · 2016-05-01
RECRUITINGNeuronavigation-guided FUS-induced BBB Opening in Alzheimer's Disease Patients and Its Effects on Brain Amyloid and TauNCT06600880 · 2027-08-01
NOT_YET_RECRUITINGCholinergic Deep Brain Stimulation for Alzheimer's DiseaseNCT05882344 · 2026-11-01
ENROLLING_BY_INVITATIONA Study to Assess THN391 in Subjects With Alzheimer's DiseaseNCT06814730 · 2025-07-17
ACTIVE_NOT_RECRUITINGNeuropsychological Evaluation in Intellectual Disability (ENDI)NCT07047963 · 2025-07-01
NOT_YET_RECRUITINGSNIFF - 3-Week Aptar CPS DeviceNCT05006599 · 2025-05-01
WITHDRAWNPMN310 in Patients With Early Alzheimer's Disease (PRECISE-AD)NCT06750432 · 2024-12-13
ACTIVE_NOT_RECRUITINGScentAware and OCT in MCI vs HCNCT06377241 · 2024-04-15
TERMINATEDStudy to Evaluate the Efficacy, Safety, and Tolerability of an Anti-MTBR Tau Monoclonal Antibody (BMS-986446) in Participants With Early Alzheimer's DiseaseNCT06268886 · 2024-03-20
ACTIVE_NOT_RECRUITINGEffects of a Widely Used Vaccine Adjuvant in Subjects With Early Alzheimer's Disease Double-blind Study to Assess the Safety and Efficacy of AD04 in Patients With Early Alzheimer's Disease - ADVANCENCT07107074 · 2023-11-08
ACTIVE_NOT_RECRUITINGA Pivotal Study of LIPUS-Brain in Patients With Early Alzheimer's DiseaseNCT05983575 · 2023-10-31
ACTIVE_NOT_RECRUITINGThe Ketogenic Diet for Alzheimer's DiseaseNCT04701957 · 2023-03-30
TERMINATEDA Pivotal Study of Sensory Stimulation in Alzheimer's Disease (HOPE Study)NCT05637801 · 2022-12-13
COMPLETEDHyperspectral Retinal Observations for the Cross-sectional Detection of Alzheimer's DiseaseNCT05604183 · 2022-11-01
UNKNOWNEngagement 2.0 Forms of Consent for Data (re-)UseNCT05229978 · 2022-08-17
COMPLETEDEardream Data Collection in Colombia Supported by ADDFNCT05570370 · 2022-08-01
UNKNOWNDigital Evaluations and Technologies Enabling Clinical Translation for ADNCT05385913 · 2022-04-01
UNKNOWNA Practical Platform for In-Home Remote Monitoring of Cognitive FrailtyNCT05754021 · 2022-02-01
COMPLETEDSenolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD) StudyNCT04685590 · 2021-12-22
ACTIVE_NOT_RECRUITINGRepurposing Nucleoside Reverse Transcriptase Inhibitors for Treatment of ADNCT04500847 · 2021-12-17
UNKNOWNAdapted Home-based Exercise Program "T&E" (Test-and-Exercise) in Persons With Alzheimer's Disease (HOPE Trial)NCT04916964 · 2021-06-30
UNKNOWNProteomics Study of Mild Cognitive Impairment and Alzheimer's DiseaseNCT04804618 · 2021-06-01
UNKNOWNRyan Companion Robot for Assisting Elderly People With Alzheimer's DiseaseNCT05052866 · 2021-04-21
COMPLETEDA Biomarker Database to Investigate Blood-Based and Digital Biomarkers in Participants Screened for Alzheimer's Disease (Bio-Hermes)NCT04733989 · 2021-04-21
COMPLETEDPilot Study to Investigate the Safety and Feasibility of AntiRetroviral Therapy for Alzheimer's DiseaseNCT04552795 · 2021-02-15
COMPLETEDEffects of Electrical Stimulation on Verbal Learning in Typical and Atypical Alzheimer's DiseaseNCT04122001 · 2020-08-17
ACTIVE_NOT_RECRUITINGNovel Dementia BiomarkersNCT04427436 · 2020-07-01
UNKNOWNJuice Plus Supplement Clinical TrialNCT04656860 · 2020-03-12
UNKNOWNA Non-Interventional Pilot Study to Explore the Role of Gut Flora in Alzheimer's DiseaseNCT04100889 · 2020-03-02
WITHDRAWNTheta-burst Stimulation on Cognitive Function in the Patients With Young-onset Alzheimer's Disease DementiaNCT04042532 · 2020-01-03
ENROLLING_BY_INVITATIONEffects of Mitochondrial-targeted Antioxidant on Mild Cognitive Impairment (MCI) PatientsNCT03514875 · 2019-11-11
WITHDRAWNEpileptiform Activity During REM Sleep in Alzheimer's DiseaseNCT03923569 · 2019-04-29
UNKNOWNThe Effect of Black Mulberry (Morus Nigra) Consumption on Cognitive FunctionsNCT05406648 · 2019-01-08
COMPLETEDEfficacy and Safety of AD-35 in Treatment of Subjects With Mild to Moderate Alzheimer's DiseaseNCT03625401 · 2018-10-04
UNKNOWNStudy of Tolerability, Safety and Efficacy of Sensory Stimulation at Multiple Dose Levels to Improve Brain Function (Etude Study)NCT03661034 · 2018-05-31
UNKNOWNEfavirenz for Patients With Alzheimer's DiseaseNCT03706885 · 2018-05-05
COMPLETEDPatients With Alzheimer's Disease or Related Youth DiseaseNCT03508024 · 2018-01-05
COMPLETEDA Safety Study of PTI-125 in Healthy VolunteersNCT03784300 · 2017-08-18
COMPLETEDThe Interactive Physical and Cognitive Exercise SystemNCT03069391 · 2017-03-04
UNKNOWNEarly-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural NetworksNCT03153371 · 2016-04-04
COMPLETEDThe Resting-state EEG Gamma Oscillations in Alzheimer's DiseaseNCT05989087 · 2012-11-07
COMPLETEDEffects of Transcranial Magnetic Stimulation (TMS) and Cognitive Training for Alzheimer PatientsNCT00909285 · 2009-07-01
COMPLETEDGenetic Studies in Familial DementiaNCT04680013 · 2007-06-01
COMPLETEDCommon interventions
PlaceboDRUG7No InterventionOTHER20.9% NaClDRUG1100 mg PTI-125DRUG1200 mg PTI-125DRUG13TCDRUG150 mg PTI-125DRUG1Active, in-person HD-tDCS or active remote tDCSDEVICE1AD-35 60mg groupDRUG1AD04DRUG1AmyvidDRUG1Aptar Pharma CPS Intranasal Delivery DeviceDEVICE1ARO-MAPT-SCDRUG1Biological Sample CollectionOTHER1Biomarker Data CollectionOTHER1Blood drawDIAGNOSTIC_TEST1blood sampleDIAGNOSTIC_TEST1blood samplePROCEDURE1BMS-986446DRUG1Brain GamesDEVICE1C-11 PiBDRUG1cognitive exercise alone (iCE) firstDEVICE1Cognitive trainingBEHAVIORAL1Cognitive TrainingDEVICE1Cognitive treatmentBEHAVIORAL1
Leading sponsors
Assistance Publique - Hôpitaux de Paris
2
Cognito Therapeutics, Inc.
2
Guangzhou University of Traditional Chinese Medicine
2
Rennes University Hospital
2
ADvantage Therapeutics
1
Arrowhead Pharmaceuticals
1
Assaf-Harofeh Medical Center
1
Baylor College of Medicine
1
Bristol-Myers Squibb
1
Butler Hospital
1
Case Western Reserve University
1
Central Hospital, Nancy, France
1
Chang Gung Memorial Hospital
1
Columbia University
1
Denali Therapeutics Inc.
1
Trial status mix
RECRUITING15
COMPLETED14
UNKNOWN12
ACTIVE_NOT_RECRUITING7
WITHDRAWN3
ENROLLING_BY_INVITATION2
NOT_YET_RECRUITING2
TERMINATED2
Phase mix
NA24
PHASE19
PHASE28
PHASE33
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Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.