Condition
Major Depression
ClinicalTrials.gov condition label
How to interpret these research links
Connected source recordsThis is the original ClinicalTrials.gov condition label, found in 294 distinct published trials. It is kept separate from a MONDO disease identifier until a specific normalization is supported. Related interventions are co-recorded in studies; they are not medical recommendations.
Data basis: current published ClinicalTrials.gov records and, where present, RxNorm, MONDO and FDA-label identifiers. See the evidence interpretation and counting methodology.
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Clinical trials
60 shownRelationship of Peripheral Inflammatory and Neuroprotective Biomarkers With Response to Intermittent Theta Burst Stimulation in Treatment-Resistant DepressionNCT07673913 · 2026-09-01
RECRUITINGPsilocybin Intervention for Veterans Overcoming Treatment-Resistant DepressionNCT07226232 · 2026-08-03
RECRUITINGInhaled DMT for Major Depressive DisorderNCT07562191 · 2026-08-01
RECRUITINGStudy on iTBS Regulating the Reward Circuit Function to Improve Anhedonia in DepressionNCT07813169 · 2026-05-19
RECRUITINGModular Intervention for Depression StudyNCT07380451 · 2026-05-01
RECRUITINGSynaptic Mechanisms of Continuous Theta Burst Stimulation in DepressionNCT07560878 · 2026-03-11
RECRUITINGEffect of Psychobiotics With Standard Antiddepressants in Treatment of Major Depressive DisorderNCT07691749 · 2026-01-31
RECRUITINGEEG Microstate Parameters and Neuroinflammatory Biomarkers in Patients With Treatment-Resistant Major Depressive Disorder Receiving ECTNCT07748091 · 2026-01-01
RECRUITINGStudy of Sleep Inertia in Major Depressive Disorder by the Psychomotor Vigilance TaskNCT06732284 · 2025-11-04
RECRUITINGValidation of a Composite Medical Device Using a Blood Biomarker-based Algorithm and MDQ for the Diagnosis of Bipolar DisorderNCT07031817 · 2025-09-30
RECRUITINGSleep TMS for DepressionNCT06824415 · 2025-05-01
RECRUITINGPharmacogenomics of Selective Serotonin Reuptake Inhibitor (SSRI)-Induced Behavioural ActivationNCT06763081 · 2025-03-01
RECRUITINGLeucine in Midlife DepressionNCT06580145 · 2025-02-01
RECRUITINGCombining Light Therapy and CPAP in DepressionNCT06781593 · 2025-01-17
RECRUITINGAdded Value of a Neuroendocrine Test Battery in the Response to Repetitive Transcranial Magnetic Stimulation (rTMS) TreatmentNCT05964192 · 2024-04-01
RECRUITINGNIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar DisorderNCT05669703 · 2023-11-03
RECRUITINGInterpersonal Psychotherapy for Adolescents and Young AdultsNCT05575960 · 2022-10-03
RECRUITINGRCT of At-Home tDCS for Depression in PregnancyNCT05097586 · 2021-11-08
RECRUITINGUniversity of Iowa Interventional Psychiatry Service Patient RegistryNCT04480918 · 2020-11-02
RECRUITINGMechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major DepressionNCT03973268 · 2020-01-21
RECRUITINGCharacterizing Cognitive Decline in Late Life Depression: The ADNI Depression ProjectNCT02434393 · 2015-03-04
RECRUITINGKetamine Alcohol (in Treatment-Resistant Depression)NCT02122562 · 2014-04-23
RECRUITINGSkills for WellnessNCT01980147 · 2014-03-22
RECRUITINGEEG-Guided Transcranial Magnetic Stimulation for Adults With DepressionNCT07862205 · 2026-11-01
NOT_YET_RECRUITINGIndividual Narratives of Stimulation (ECT and TMS)NCT07807930 · 2026-11-01
NOT_YET_RECRUITINGShortened LSD Intervention for Major Depressive DisorderNCT07503002 · 2026-10-01
NOT_YET_RECRUITINGSingle Day of Ultra-accelerated TMS With a Single Dose of NRX-101NCT07785102 · 2026-09-01
NOT_YET_RECRUITINGEvaluation of an 8-week Behavior Skills-based Virtual Reality Program for Adolescents With Depression. (MDD)NCT07807735 · 2026-09-01
NOT_YET_RECRUITINGSynaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive DisorderNCT07593222 · 2026-09-01
NOT_YET_RECRUITINGNon-Coding RNAs Gene Expression in Psychiatric DisordersNCT07649993 · 2026-09-01
NOT_YET_RECRUITINGAssessing of Behavioral Risk and Response to Electromagnetic and Psychedelic TherapiesNCT07745569 · 2026-08-31
NOT_YET_RECRUITINGStudy of Psilocybin Under Anesthesia Controlled by EEGNCT07479550 · 2026-07-01
NOT_YET_RECRUITINGiTBS Versus Standard 10 Hz rTMS for Treatment-Resistant Depression (TRD)NCT07852065 · 2026-06-30
ACTIVE_NOT_RECRUITINGAccelerated High-Dose tDCS for DepressionNCT07226011 · 2025-12-15
ACTIVE_NOT_RECRUITINGLifestyle MIND- Feasibility of Wait-list ControlNCT06384521 · 2025-12-01
WITHDRAWNEfficacy and Safety of Task-specific, Biomarker-driven, HD-ctACS inTRD.NCT07184697 · 2025-08-14
ACTIVE_NOT_RECRUITINGA Randomized Control Trial of Enhanced Cognitive Behavioural Group Therapy for Older Adults with Depression: Efficacy Across Older Age-GroupsNCT06894641 · 2025-07-01
NOT_YET_RECRUITINGThe Brain-Heart-Gut ConnectionNCT06748274 · 2025-06-01
COMPLETEDTreatment Response In ECT PatientsNCT07463911 · 2025-05-20
ACTIVE_NOT_RECRUITINGMonPsy&Moi: A Digital Platform for Collecting Patient-Reported Experience and Outcome Measures in PsychiatryNCT06818227 · 2025-02-02
NOT_YET_RECRUITINGTranscranial Magnetic Stimulation in Patients with Dual DisordersNCT06765824 · 2025-02-01
NOT_YET_RECRUITINGCommon Factors Group Psychotherapy for General Mental Health ConcernsNCT06614842 · 2025-01-17
WITHDRAWNEffect of Aerobic Exercise on Biomarkers in DepressionNCT07062783 · 2024-08-01
COMPLETEDCombining rTMS and tDCS in Depression: an Exploratory Clinical TrialNCT06500533 · 2024-07-31
TERMINATEDOpen-Label Dose-Ranging Study of Oral SM-001 in Healthy AdultsNCT05894902 · 2023-10-01
UNKNOWNpBFS Guided VS "5-cm Rule" rTMS Over DLPFC for MDDNCT05964023 · 2023-08-20
UNKNOWNTranscranial Pulse Stimulation for DepressionNCT05551585 · 2023-06-01
COMPLETEDEffectiveness of mHealth Post-discharge Intervention for Patients With Severe Mental IllnessNCT05703412 · 2023-02-14
ENROLLING_BY_INVITATIONAI-based Multi-center Research on Identification/Classification/Aided Diagnosis of Mood DisorderNCT05608135 · 2022-12-01
UNKNOWNClinical Effectiveness of Choline Alphoscerate for Older Adults With Major Depression and Subjective Memory ComplaintsNCT05257902 · 2022-08-19
COMPLETEDTBS Over DLPFC in Elderly Refractory DepressionNCT04872465 · 2022-07-06
UNKNOWNNon-interventional, Retrospective Cohort Study to Explore Antidepressant Treatment in KoreaNCT04446039 · 2022-07-04
COMPLETEDHigh-Frequency vs. Theta-Burst TMS for DepressionNCT07181226 · 2022-05-01
COMPLETEDAcupoint Thermal Radiation Characteristics in Adolescents with MDDNCT06750640 · 2022-03-05
COMPLETEDNeuroimaging Sleep and Mood in DepressionNCT05497414 · 2022-01-31
COMPLETEDOnline System for Identifying and Addressing Teen Depression in Primary CareNCT04489485 · 2021-02-01
UNKNOWNEffects of Vitamin D Supplementation on Depression and Inflammatory MarkersNCT04898725 · 2020-12-25
COMPLETEDStress Management and Resiliency Training for Depression vs Treatment as Usual in the Treatment of Major DepressionNCT04388748 · 2020-12-18
COMPLETEDImplementation of Harmonized Depression Outcome Measures in a Health SystemNCT04235712 · 2020-11-17
COMPLETEDRCT Study on the Therapeutic Effect of Escitalopram Loaded With XingpiJieyu Formula on Resting State EEG Energy Abnormalities in Severe Liver Depression and Spleen Deficiency Type MDDNCT06758167 · 2020-11-14
COMPLETEDCommon interventions
PlaceboDRUG22EscitalopramDRUG19SertralineDRUG7DuloxetineDRUG6fluoxetineDRUG6KetamineDRUG6Interpersonal PsychotherapyBEHAVIORAL5TMSDEVICE5BupropionDRUG4CitalopramDRUG4Cognitive behavior therapyBEHAVIORAL3Cognitive Behavioral TherapyBEHAVIORAL3DesvenlafaxineDRUG3ParoxetineDRUG3RisperidoneDRUG3tDCS (Eldith DC-Stimulator (CE certified))DEVICE3Transcranial Magnetic Stimulation (TMS)DEVICE3TriiodothyronineDRUG3venlafaxineDRUG3VortioxetineDRUG3active tDCSDEVICE2Attention Bias ModificationBEHAVIORAL2D-cycloserineDRUG2Electroconvulsive therapyPROCEDURE2Electroconvulsive therapyDEVICE2
Leading sponsors
National Institute of Mental Health (NIMH)10New York State Psychiatric Institute8The University of New South Wales8Massachusetts General Hospital7Centre for Addiction and Mental Health5Charite University, Berlin, Germany5University of Pittsburgh5Weill Medical College of Cornell University5Emory University4Hillerod Hospital, Denmark4Karolinska Institutet4Mclean Hospital4University of California, Los Angeles4US Department of Veterans Affairs4VA Office of Research and Development4
Trial status mix
COMPLETED187
UNKNOWN35
RECRUITING23
TERMINATED22
NOT_YET_RECRUITING12
WITHDRAWN8
ACTIVE_NOT_RECRUITING5
ENROLLING_BY_INVITATION1
SUSPENDED1
Phase mix
NA133
PHASE450
PHASE235
PHASE321
PHASE118
EARLY_PHASE12
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Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.