Intervention

Ketamine

ClinicalTrials.gov intervention label

How to interpret these research links

Connected source records

This is the original ClinicalTrials.gov intervention label, found in 115 distinct published trials. Registry interventions may represent drugs, devices, procedures or other study activities. A matched term or study association does not establish product equivalence, efficacy or regulatory approval.

Data basis: current published ClinicalTrials.gov records and, where present, RxNorm, MONDO and FDA-label identifiers. See the evidence interpretation and counting methodology.

Clinical trials115

Recruiting17

Common conditions25

Lead sponsors shown15

Clinical trials

60 shown

Biomarker-Guided Antidepressant SelectionNCT07680140 · 2026-08-10

Ketamine for Veterans With Parkinson's DiseaseNCT06231563 · 2026-03-01

ACT_for Alcohol Use Disorder and DepressionNCT06620276 · 2025-05-01

Intravenous Ketamine for Treatment-Resistant DepressionNCT06668571 · 2025-02-10

Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of DepressionNCT06559826 · 2025-01-10

Early Effects of Ketamine vs Placebo With Venlafaxine in Severe Depression PatientsNCT06508710 · 2024-10-20

Pharmacologic Treatment Augmentation in Chronic DepressionNCT06410599 · 2024-04-29

Neural Circuit Effects of Ketamine in DepressionNCT06213324 · 2024-01-31

Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant DepressionNCT06480201 · 2024-01-01

RIVER At Home Ketamine ProtocolsNCT06070766 · 2023-10-01

Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine ResponseNCT05915013 · 2023-09-07

The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal EffectsNCT05786066 · 2023-04-03

Glutamatergic Adaptation to Stress as a Mechanism for Anhedonia and Treatment Response With KetamineNCT05327699 · 2022-11-08

Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With DepressionNCT05450432 · 2022-10-13

University of Iowa Interventional Psychiatry Service Patient RegistryNCT04480918 · 2020-11-02

Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive DisorderNCT03065335 · 2017-05-25

Ketamine Alcohol (in Treatment-Resistant Depression)NCT02122562 · 2014-04-23

Ultrasound Guided Pecs Block and Ketamine Infusion for Preventing Chronic Pain in Patients Undergoing Breast Cancer SurgeryNCT07197684 · 2026-03-16

NOT_YET_RECRUITING

Ketamine-Enhanced Therapy for Individuals With Alcohol Use Disorder and Depression: A Pilot Study (KET-DUAL)NCT07247370 · 2025-12-10

NOT_YET_RECRUITING

Electroconvulsive Therapy Versus Intravenous Ketamine in Treatment-Resistant Major Depressive DisorderNCT07526454 · 2025-07-01

Ketamine-Assisted Recovery for Methamphetamine Use Disorder & HIVNCT06538285 · 2025-03-04

Predictors of Intravenous Ketamine Response in TRDNCT05625555 · 2024-01-19

ACTIVE_NOT_RECRUITING

Opioid-Free Pain Control Regimen Following Robotic Radical ProstatectomyNCT05597878 · 2023-04-18

Ketamine for Multiple Sclerosis FatigueNCT05378100 · 2023-01-01

ACTIVE_NOT_RECRUITING

The Effect of Ketamine on Aesthetics and Role for Antidepressant EffectsNCT05320107 · 2022-06-01

Low-dose Ketamine Infusion Among Adolescents With Treatment-resistant DepressionNCT05045378 · 2022-03-15

Synaptic Imaging and Network Activity in Treatment Resistant DepressionNCT05870501 · 2021-10-20

Randomized, Double-Blind, Active Placebo-Controlled Study of Ketamine to Treat Levodopa-Induced DyskinesiaNCT04912115 · 2021-10-05

Intraperitoneal Dexmedetomidine Versus Ketamine With Bupivacaine For Postoperative AnalgesiaNCT04525274 · 2021-10-01

Glutamate and Opioid Mechanisms of Antidepressant Response to KetamineNCT04977674 · 2021-09-27

Ketamine As an Adjunctive Therapy for Major Depression (2)NCT04939649 · 2021-09-13

Naturalistic Study of Ketamine in the Treatment of DepressionNCT05249309 · 2021-05-01

Ketamine Infusion vs Dexmedetomidine Infusion in Obese Patients Undergoing Bariatric SurgeryNCT04576975 · 2021-04-20

Analgesia Management in Bariatric SurgeryNCT04836819 · 2021-04-08

Ketamine Treatment Effects on Synaptic Plasticity in DepressionNCT04091971 · 2020-10-09

Role Of Ketamine in Treatment-Resistant Major Depressive Disorder And Its Effect on SuicidalityNCT04101474 · 2020-09-01

Ketamine Versus Magnesium Sulphate as Adjuvants for ESPB in Breast Cancer SurgeryNCT04275661 · 2020-08-01

The Role of Ketamine as an Adjuvant Therapy for Children With Acute Status AsthmaticusNCT03338205 · 2020-01-01

A Naturalistic Study of Ketamine for Treatment Resistant Mood DisordersNCT04226963 · 2019-12-04

Magnesium and Ketamine in Postoperative AnalgesiaNCT04111848 · 2019-11-01

Effectiveness of Ketamine for Depression and Suicidal Ideation in the Emergency DepartmentNCT04266288 · 2019-10-18

Repeated Ketamine Infusions for Comorbid PTSD and MDD in VeteransNCT04032301 · 2019-09-30

Ketamine or Placebo in Patients With Major Depression and Advanced CancerNCT04471818 · 2019-09-19

Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac SurgeryNCT03861988 · 2019-08-22

Ketamine for Mood Disorders With Suicidal IdeationNCT04099771 · 2019-07-01

Effects of Ketamine on Mentalizing and Metacognition in Healthy VolunteersNCT05320991 · 2019-06-15

Comparison of Ketamine Combine Propofol vs Propofol Anesthesia in Schizophrenia Electroconvulsive TherapyNCT03829124 · 2019-05-24

The Role of HNKs in the Antidepressant Effect of KetamineNCT03977675 · 2019-05-15

Proof of Concept Study Evaluating the Efficacy and Safety of MIJ821 in Patients With Treatment-resistant DepressionNCT03756129 · 2019-02-08

Ketamine Associated ACC GABA and Glutamate Change and Depression Remission:NCT03573349 · 2019-01-03

ACTIVE_NOT_RECRUITING

Sedation of Morbidly Obese for Balloon InsertionNCT03747094 · 2018-12-01

Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot TrialNCT03367533 · 2018-11-29

Using a Low Dose of Ketamine vs. Active Placebo in Treating Severe Depression and SuicideNCT03666390 · 2018-09-10

Ketamine for Treatment Resistant MDDNCT04021433 · 2018-09-01

Ketamine for Treatment of MS FatigueNCT03500289 · 2018-08-10

Ketamine as an Adjunctive Therapy for Major DepressionNCT03256162 · 2017-09-07

ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)NCT03113968 · 2017-04-07

Ketamine vs HydromorphoneNCT03001843 · 2017-02-22

Open Label Ketamine Treatment for Major Depressive Disorder in VeteransNCT03053830 · 2017-01-31

Ketamine's Effect Changes the Cortical Electrophysiological Activity Related to Semantic Affective Dimension of PainNCT03915938 · 2017-01-02

Common conditions

Leading sponsors

Yale University7 Massachusetts General Hospital6 James Murrough4 Icahn School of Medicine at Mount Sinai3 Janssen Research & Development, LLC3 Mayo Clinic3 New York State Psychiatric Institute3 Assiut University2 Baylor College of Medicine2 Columbia University2 Hospital de Clinicas de Porto Alegre2 Johns Hopkins University2 King's College London2 Mark Niciu2 National Institute of Mental Health (NIMH)2

Trial status mix

COMPLETED67

RECRUITING17

UNKNOWN13

TERMINATED8

ACTIVE_NOT_RECRUITING4

WITHDRAWN3

NOT_YET_RECRUITING2

SUSPENDED1

Phase mix

PHASE235

PHASE424

NA23

PHASE122

PHASE312

EARLY_PHASE16

Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.