Condition

Major Depressive Disorder (MDD)

ClinicalTrials.gov condition label

How to interpret these research links

Connected source records

This is the original ClinicalTrials.gov condition label, found in 204 distinct published trials. It is kept separate from a MONDO disease identifier until a specific normalization is supported. Related interventions are co-recorded in studies; they are not medical recommendations.

Data basis: current published ClinicalTrials.gov records and, where present, RxNorm, MONDO and FDA-label identifiers. See the evidence interpretation and counting methodology.

Clinical trials204

Recruiting65

Common interventions25

Lead sponsors shown15

Clinical trials

60 shown

Sertraline Combined With Multi-Strain Probiotics for Adolescent DepressionNCT07645157 · 2026-10-01

Precision Depression Adalimumab TrialNCT07845604 · 2026-09-01

Accelerated iTBS for PTSD and DepressionNCT07682207 · 2026-09-01

Inhaled DMT for Major Depressive DisorderNCT07562191 · 2026-08-01

Evaluating Conversational Artificial Intelligence for Depression ManagementNCT07105397 · 2026-07-22

Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT)NCT07569198 · 2026-07-16

A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)NCT07621237 · 2026-06-25

Efficacy and Safety of Sertraline Combined With Lactobacillus Crispatus in Adolescents With DepressionNCT07539805 · 2026-06-11

Pattern Separation in Major Depressive DisorderNCT07139834 · 2026-06-01

Repeated Real-time Biofeedback With 7-Tesla MRI for Treatment of DepressionNCT07694076 · 2026-06-01

Cannabidiol Oil for Treatment-Resistant Major DepressionNCT07696871 · 2026-06-01

A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With DepressionNCT07610473 · 2026-05-14

Investigating Functional Changes in the Frontotemporal Cortex of Patients With Major Depressive Disorder Following Electroconvulsive Therapy or Magnetic Seizure Therapy Using Functional Near-infrared Spectroscopy (fNIRS)NCT07533773 · 2026-04-30

Mechanisms Of Orbitofrontal Stimulation in DepressionNCT07230990 · 2026-04-15

Identification and Molecular Characterisation of Urban-environmental Stress Patterns Affecting Mental IllnessNCT07571226 · 2026-04-10

Efficacy of Bright Light Therapy on Cognitive Impairment in Major Depressive Disorder and Its Neuroimaging Mechanisms: Protocol for a Randomised Controlled TrialNCT07508215 · 2026-04-10

Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of KetamineNCT06788249 · 2026-04-01

Accelerated iTBS for Major DepressionNCT07603804 · 2026-03-08

Feasibility Trial of Exercise as a Priming Strategy for rTMS Treatment in Difficult-to-Treat DepressionNCT06773949 · 2026-03-01

Double-blind, Placebo-controlled Study in Adults With Major Depressive DisorderNCT07226661 · 2026-01-19

Electroconvulsive Therapy Augmented With Transcranial Magnetic Stimulation for Treatment Resistant DepressionNCT07324070 · 2026-01-05

Home-Based tDCS for Depression in BPDNCT06972368 · 2026-01-01

A Study to Evaluate the Effectiveness of DT-101 in Patients With DepressionNCT07300969 · 2025-12-16

A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive DisorderNCT06793397 · 2025-12-10

Neurofeedback to Treat Depression - 2NCT07159061 · 2025-11-21

Dextromethorphan-Bupropion on Striatal Activity in Adults With Major Depressive DisorderNCT07523048 · 2025-11-21

Home-Based Transcranial Direct Current Stimulation In Major Depressive Disorder (HOME)NCT07228468 · 2025-11-18

ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant ResponseNCT07284667 · 2025-11-14

Improving Outcomes in Adolescent Inpatient Depression With Deep Transcranial Magnetic StimulationNCT07217444 · 2025-11-13

Biomarker Research on Ultra-High-Field MRI Combined With Visual Perception Assessment in the Diagnosis and Treatment Outcomes of Severe Mental DisordersNCT07479758 · 2025-11-01

Group Therapy for Major Depression: Comparing Expectation-Focused and Reward-Focused Psychotherapy ApproachesNCT07388004 · 2025-10-13

tVNS, Motivation, and Insulin SensitivityNCT07198100 · 2025-10-10

Accelerated TMS for Treatment-Resistant ECTNCT07115628 · 2025-10-01

Lifestyle Interventions to Prevent Cognitive Deficits in Subjects With Depressive Symptoms: From Mechanisms to Clinical PracticeNCT07009223 · 2025-10-01

Lifestyle Interventions to Prevent cOgnitive Deficits in Subjects With Depressive Symptoms: From mEchanisms to Clinical pRacticeNCT07462013 · 2025-10-01

Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety StudyNCT07217223 · 2025-09-27

Orexin Antagonism for Suicide Risk: A Proof-of-Concept Clinical TrialNCT06854224 · 2025-09-01

Physical Therapy for Depression Quality of Life (Pilot Study Protocol)NCT06983405 · 2025-09-01

The Role of mGluR5 in CBT-INCT07076342 · 2025-08-01

Accelerated Neuromodulation of Anterior Cingulate Cortex for DepressionNCT07212465 · 2025-07-21

Validation of EmoDTx as a Digital Endpoint for Mood Monitoring in Adult Patients Suffering From Unipolar DepressionNCT06860165 · 2025-07-15

Accelerated Intermittent Theta Burst Stimulation for Adolescent and Young Adult Depression With Elevated Suicide RiskNCT07025720 · 2025-07-01

Psilocybin Therapy for Psychological Distress in Palliative PatientsNCT06782724 · 2025-07-01

Home-Based tDCS Treatment Of Major Depressive DisorderNCT06976697 · 2025-06-27

A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)NCT07065240 · 2025-06-19

Moving on After Breast Cancer Trial for Depressed Breast Cancer Survivors in PakistanNCT07015944 · 2025-06-13

Gender Differences in Depression Severity, Gender-Sensitive Symptoms, Resilience, and Stigma in Major Depressive DisorderNCT07474363 · 2025-06-01

Theta-Burst Stimulation to Treat DepressionNCT07033780 · 2025-06-01

EEG-based Neurofeedback to Improve Emotion Regulation in Major Depressive Disorder: A Randomized Clinical TrialNCT07041073 · 2025-05-19

Validation of the CIDI 5.0 Against the SCID-5 for Lifetime Mental DisordersNCT07604753 · 2025-05-14

VR Pupillometry in Cognitive ImpairmentNCT07402356 · 2025-05-01

Cognitive Rehabilitation for Veterans With MDD-related Cognitive Functioning DeficitsNCT06728774 · 2025-05-01

A Trial of Dextromethorphan and Bupropion Sustained-Release Tablets in Patients With Major Depressive DisorderNCT06958692 · 2025-04-11

Understanding and Treating Suicidal Ideation With KetamineNCT06891300 · 2025-04-08

Evaluation of the Concordance Between Measures Obtained by a Medical Device for Emotional Monitoring (EMOCARE) and the Patient Health Questionnaire (PHQ-9) Score in Patients With Mild to Severe Depressive EpisodeNCT06601140 · 2025-03-05

Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive DisorderNCT06830044 · 2025-03-03

LHC-CIDI-5 in Hong KongNCT06804525 · 2025-01-18

Assessment of the Efficacy and Safety of Fecal Microbiota Transplantation (FMT) in Patients With Major Depressive DisorderNCT06692361 · 2025-01-01

Neurobiological and Genomic Predictors of Relapse in DepressionNCT07328373 · 2025-01-01

Predictors of Relapse in Major Depressive Disorder (PERFORM-D)NCT06746155 · 2024-12-27

Common interventions

Leading sponsors

GlaxoSmithKline10 Otsuka Pharmaceutical Development & Commercialization, Inc.7 Shanghai Mental Health Center6 Central South University4 Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau4 Chengdu Kanghong Pharmaceutical Group Co., Ltd.3 CSPC ZhongQi Pharmaceutical Technology Co., Ltd.3 IRCCS Centro San Giovanni di Dio Fatebenefratelli3 The University of Hong Kong3 University of Pennsylvania3 Capital Medical University2 Centre for Addiction and Mental Health2 Draig Therapeutics Ltd2 Eli Lilly and Company2 Emobot2

Trial status mix

RECRUITING65

COMPLETED60

NOT_YET_RECRUITING46

UNKNOWN9

ACTIVE_NOT_RECRUITING7

ENROLLING_BY_INVITATION7

TERMINATED7

WITHDRAWN2

SUSPENDED1

Phase mix

NA81

PHASE243

PHASE326

PHASE114

PHASE411

EARLY_PHASE12

Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.