Disease & disorder

acute myocardial infarction

MONDO:0004781

Necrosis of the myocardium, as a result of interruption of the blood supply to the area. It is characterized by a severe and rapid onset of symptoms that may include chest pain, often radiating to the left arm and left side of the neck, dyspnea, sweating, and palpitations.

Clinical trials75
Recruiting6
Drug concepts studied13
Synonyms2

Research intelligence

Directly mapped studies only · unique clinical trials

Current registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.

Medications under investigation

Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.

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MONDO disease family

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Recruiting studies by city

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Investigated drug interventions

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Background context

Myocardial infarction

A myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops in one of the arteries of the heart, causing infarction (tissue death) to the heart muscle. The most common symptom is retrosternal chest pain or discomfort that classically radiates to the left shoulder, arm, or jaw. The pain may occasionally feel like heartburn. This is the dangerous type of acute coronary syndrome. Other symptoms may include shortness of breath, nausea, feeling faint, a cold sweat, feeling tired, and decreased level of consciousness. Women more often present without chest pain and instead have neck pain, arm pain or feel tired. Among those over 70-75 years old, about 5% have had an MI with little or no history of symptoms. An MI may cause heart failure, an irregular heartbeat, cardiogenic shock or cardiac arrest. Most MIs occur due to coronary artery disease. Risk factors include high blood pressure, smoking, diabetes, lack of exercise, obesity, high blood cholesterol, poor diet, and excessive alcohol intake. The complete blockage of a coronary artery caused by a rupture of an atherosclerotic plaque is usually the underlying mechanism of an MI. MIs are less commonly caused by coronary artery spasms, which may be due to cocaine, significant emotional stress (often known as Takotsubo syndrome or broken heart syndrome) and extreme cold, among others. Many tests are helpful with diagnosis, including electrocardiograms (ECGs), blood tests and coronary angiography. An ECG, which is a recording of the heart's electrical activity, may confirm an ST elevat...

Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.

Clinical trials

40 shown
Using an Intervention Adapted to the Health Literacy Level to Improve Adherence to Medical RecommendationsNCT03951467 · 2025-06-26
RECRUITING
Clinical Evaluation of NIRSense Tissue Oximetry Sensor Monitoring to Early Detect Cardiogenic ShockNCT07825363 · 2025-06-17
RECRUITING
Study of Patients Admitted to a Cardiac Intensive Care Unit With Acute CardioVascular DiseaseNCT06081205 · 2023-04-27
RECRUITING
CT Stress Myocardial Perfusion, Fractional Flow Reserve and Angiography in Patients With Stable Chest Pain SyndromesNCT04709900 · 2021-12-03
RECRUITING
Assessment of ECMO in Acute Myocardial Infarction Cardiogenic ShockNCT04184635 · 2021-10-14
RECRUITING
Peri-treatment of SGLT-2 Inhibitor on Myocardial Infarct Size and Remodeling Index in Patients With Acute Myocardial Infarction and High Risk of Heart Failure Undergoing Percutaneous Coronary InterventionNCT04899479 · 2021-07-05
RECRUITING
The Benefits of Wearable AI in Post-Discharge Management of AMI PatientsNCT07288229 · 2025-12-30
NOT_YET_RECRUITING
Noninvasive Assessment of Pulmonary Fluid Levels by Remote Dielectric Sensing Technology to Improve Cardiac InsUfficieney During Ischemia-Reperfusion and Clinical Outcomes in MyocArdiaL InfarctionNCT06671067 · 2024-11-01
NOT_YET_RECRUITING
Effect of Oral Semaglutide on Epicardial and Pericoronary Adipose Tissues in Type 2 Diabetes After Myocardial InfarctionNCT06557811 · 2024-09-01
UNKNOWN
Influence of Enteral Microbiome on Mortality of Patients With Cardiogenic ShockNCT06006754 · 2023-08-30
COMPLETED
Addressing Social Vulnerabilities in Cardiovascular DiseaseNCT03613064 · 2023-06-01
WITHDRAWN
Pulmonary Hypertension on Prognosis of Acute Myocardial Infarction Patients With Reduced Left Ventricular FunctionNCT06186713 · 2023-03-30
COMPLETED
Glucose Monitoring After Acute Myocardial Infarct in People With DiabetesNCT05431296 · 2023-02-07
UNKNOWN
Mulltimodal Dynamic Risk Assessment Systems of Heart Failure in Patients With Myocardial Infarction.NCT05760157 · 2023-01-01
UNKNOWN
Algarve Active Ageing - Cardiac and Osteoarthritis Rehabilitation (A3-COR)NCT05999110 · 2022-06-01
UNKNOWN
The Use of a Monitoring Device by General Practitioners During Out-of-hours CareNCT05222711 · 2022-05-01
UNKNOWN
Metformin and Prevention of Cardiovascular Events in Patients With Acute Myocardial Infarction and Prediabetes (MIMET)NCT05182970 · 2021-12-02
UNKNOWN
The SWISSHEART Failure Network (SHFN)NCT05603247 · 2021-11-01
UNKNOWN
MSCs for Prevention of MI-induced HFNCT05043610 · 2021-09-15
COMPLETED
Twenty-year Follow-up of the Inter99 CohortNCT05166447 · 2021-09-13
ENROLLING_BY_INVITATION
Improving Cardiac Rehabilitation Outcomes Through Mobile Case Management (iCARE)NCT04938661 · 2021-07-08
COMPLETED
Dapagliflozin Effects on Mayor Adverse Cardiovascular Events in Patients With Acute Myocardial Infarction (DAPA-AMI)NCT04717986 · 2021-01-26
COMPLETED
Dapagliflozin Effects on Cardiometabolic Outcomes in Patients With an Acute Heart Attack.NCT04564742 · 2020-12-22
COMPLETED
Switching From Cardiac Troponin I to TNCT05748691 · 2020-10-25
COMPLETED
Optimized Cardioprotection Therapy in Obese Subjects With AMINCT04570514 · 2020-10-01
UNKNOWN
The Development of Quantitative Ultrasound Imaging Software PlatformNCT05836246 · 2020-09-01
UNKNOWN
Prognostic Value of Lung Ultrasound in ST Segment Elevation Acute Myocardial Infarction (LUS-AMI)NCT04526535 · 2020-06-15
COMPLETED
Inflammation-mediated Coronary Plaque Vulnerability, Myocardial Viability and Ventricular RemodelingNCT03830944 · 2019-07-25
COMPLETED
Pilot Study of ILIADE : Exploring Health Literacy Within Patients Hospitalized for Acute Cardiovascular EventsNCT03949309 · 2019-06-24
COMPLETED
Enhancing Cardiac Rehabilitation Through Behavioral NudgesNCT03834155 · 2019-05-17
COMPLETED
Stress Management Modified Cardiac Rehabilitation in Patients After Acute Myocardial Infarction or Heart FailureNCT03905187 · 2019-04-16
UNKNOWN
Iron in Patients With Cardiovascular DiseaseNCT03991000 · 2019-02-28
TERMINATED
Metabolomics and Microbiomics in Cardiovascular DiseasesNCT04146701 · 2019-02-01
UNKNOWN
Flublok v. Standard Dose Vaccine Effectiveness Among Kaiser Permanente Northern California Adults 18-64 YearsNCT03694392 · 2018-09-16
COMPLETED
Psyhosomatic Medicine in Oncologic and Cardiac Disease StudyNCT03437642 · 2018-03-27
UNKNOWN
Incidence Rate of Heart Failure After Acute Myocardial Infarction With Optimal TreatmentNCT03297164 · 2017-12-21
COMPLETED
Impact of EMpagliflozin on Cardiac Function and Biomarkers of Heart Failure in Patients With Acute MYocardial InfarctionNCT03087773 · 2017-05-11
COMPLETED
Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MINCT02924727 · 2016-12-09
COMPLETED
Evaluation of Novel Risk Factors and Clinical Outcomes of Acute Myocardial InfarctionNCT02641184 · 2015-12-01
UNKNOWN
Copeptin Registry (proCORE) Biomarkers in Cardiology (BIC)-19NCT02490969 · 2015-09-01
COMPLETED

Leading sponsors

Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.