Drug & intervention
anakinra
RxCUI 72435
RxNorm ingredient and formulation relationships
Source-verified product relationships. Every strength, delivery form and RxCUI remains a separate clinical concept.
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Background context
Anakinra
Anakinra, sold under the brand name Kineret, is a biopharmaceutical medication used to treat rheumatoid arthritis, cryopyrin-associated periodic syndromes, familial Mediterranean fever, and Still's disease. It is a slightly modified recombinant version of the human interleukin 1 receptor antagonist protein. It is marketed by Swedish Orphan Biovitrum. Anakinra is administered by subcutaneous injection.
Background only. Canonical identity remains RxNorm; clinical-trial relationships come from ClinicalTrials.gov.Clinical trials
33 shownThe Effects of IL-1 Blockade on Inotrope Sensitivity in Patients With Heart Failure (AID-HEART)NCT06062966 · 2024-02-05
COMPLETEDHyperinsulinemia in Prediabetes Mediated by Interleukin-1βNCT05854251 · 2023-06-15
COMPLETEDA Study of Anakinra in Japanese Patients With Still's Disease (SJIA and AOSD)NCT05814159 · 2022-08-24
ACTIVE_NOT_RECRUITINGEmpagliflozin and Anakinra for the Treatment of Postprandial Hypoglycemia in Patients With PrediabetesNCT05174507 · 2022-06-24
WITHDRAWNInterleukin-1 Blockade in Acute Myocardial Infarction to Prevent Heart FailureNCT05177822 · 2022-05-24
ACTIVE_NOT_RECRUITINGDupilumab_Metastatic NSCLCNCT05013450 · 2021-09-10
ACTIVE_NOT_RECRUITINGAnakinra as a Rescue Treatment for Allergic InflammationNCT04035109 · 2019-12-16
WITHDRAWNA Study of CART-PSMA-TGFβRDN in Patients With Metastatic Castration Resistant Prostate CancerNCT04227275 · 2019-11-22
TERMINATEDAnakinra for the Treatment of Chronically Inflamed White Matter Lesions in Multiple SclerosisNCT04025554 · 2019-10-25
COMPLETEDInterleukin-1 Blockade In Recently Decompensated Heart Failure - 2NCT03797001 · 2019-01-04
COMPLETEDStem Cell Mobilization (Plerixafor) and Immunologic Reset in Type 1 Diabetes (T1DM)NCT03182426 · 2017-08-15
COMPLETEDInterleukin-1 Blockade for the Treatment of Heart Failure in Patients With Advanced Chronic Kidney DiseaseNCT03062176 · 2017-04-03
WITHDRAWNRole of Interleukin (IL)-1 in Postprandial Fatigue - The Chäschüechli 2 StudyNCT02916355 · 2016-08-01
COMPLETEDPilot Study of the Safety and Efficacy of Anakinra in Pulmonary Arterial HypertensionNCT03057028 · 2016-04-01
COMPLETEDEffects of Interleukin-1 Beta on Low Testosterone Levels in Men With Obesity and Metabolic SyndromeNCT02672592 · 2016-01-01
COMPLETEDAnakinra, A Recombinant Human IL-1 Receptor Antagonist for Neuroinflammation in HIV-1 InfectionNCT02527460 · 2015-08-17
TERMINATEDInterleukin-1 Receptor Antagonist for the Treatment of Heart Failure in Patients With Left Ventricular Assist DevicesNCT02547766 · 2015-04-01
COMPLETEDEffects of IL-1 Beta on the HPA-axis in Obese PersonsNCT02227420 · 2014-10-01
COMPLETEDInterleukin-1 Blockade in HF With Preserved EFNCT02173548 · 2014-09-01
COMPLETEDClinical Study to Evaluate the Efficacy of Anakinra in Patients With Rheumatoid Arthritis and DiabetesNCT02236481 · 2013-07-01
TERMINATEDKineret in the Treatment of Rheumatoid ArthritisNCT02915094 · 2012-10-01
COMPLETEDAnti-IL-1 Treatment in Children Diabetic Keto-Acidosis (DKA) at Diagnosis of Type 1 DiabetesNCT01477476 · 2012-03-01
WITHDRAWNPilot Feasibility Study of the Safety and Efficacy of Anakinra in Heart Failure With Preserved Ejection FractionNCT01542502 · 2012-02-01
COMPLETEDEffects of Interleukin-1 Inhibition on Vascular and Left Ventricular Function in Rheumatoid Arthritis Patients With Coronary Artery DiseaseNCT01566201 · 2011-03-01
COMPLETEDPilot Study of the Safety and Efficacy of Anakinra (Recombinant Human Interleukin-1 Receptor Antagonist) in Heart FailureNCT01300650 · 2011-02-01
COMPLETEDThe Effect of Anakinra on Insulin SecretionNCT01285232 · 2011-01-01
UNKNOWNAnakinra to Prevent Adverse Post-infarction Remodeling (2)NCT01175018 · 2010-07-01
COMPLETEDAnti-Interleukin-1 in Diabetes ActionNCT00711503 · 2009-01-01
COMPLETEDAnti-inflammatory Therapy With Anakinra in Newly Diagnosed Type 1 DiabetesNCT00645840 · 2008-03-01
COMPLETEDTreatment of Refractory Adult-onset Still's Disease With Anakinra: a Randomized StudyNCT01033656 · 2005-12-01
COMPLETEDThe SPECTRA StudyNCT00537667 · 2001-08-01
TERMINATEDEvaluation of the Efficacy of Combination Treatment With Anakinra and Pegsunercept in Improving Rheumatoid ArthritisNCT00037700 · 2001-05-01
COMPLETEDJuvenile Rheumatoid ArthritisNCT00037648 · 2000-07-01
COMPLETEDConditions being studied
Heart Failure6Rheumatoid Arthritis4Heart Failure, Systolic2Inflammation2Acute Myocardial Infarction1Adiposity1Adult-Onset Still's Disease1Arthritis, Rheumatoid1Asthma, Allergic1Chronic Kidney Diseases1Coronary Artery Disease1Diabetes Mellitus Type 21Diabetes Mellitus, Type 11Diabetes Mellitus, Type 21Glucose Intolerance1Heart Failure With Normal Ejection Fraction1HIV Infections1Hyperinsulinemia1Hypersecretion; Cortisol1Hypogonadism1
Research locations
RichmondVirginia, United States8BaselSwitzerland4BethesdaMaryland, United States2New YorkNew York, United States2AarhusDenmark1AuroraColorado, United States1BaltimoreMaryland, United States1BarcelonaSpain1BialystokPoland1CharlottesvilleVirginia, United States1CopenhagenDenmark1DallasTexas, United States1
Leading sponsors
Virginia Commonwealth University9University Hospital, Basel, Switzerland5Amgen3National Institute of Neurological Disorders and Stroke (NINDS)2Swedish Orphan Biovitrum2Prof. Roberto Giacomelli1Radboud University Medical Center1Steno Diabetes Center Copenhagen1Tceleron Therapeutics, Inc.1Thomas Marron1University of Alberta1University of Athens1University of Colorado, Denver1University of Helsinki1University of North Carolina, Chapel Hill1
Drug identity and terminology: RxNorm. Trial relationships: ClinicalTrials.gov.