Disease & disorder

congenital heart disease

MONDO:0005453

A heart disease that is present at birth. Representative examples include atrial septal defect, ventricular septal defect, tetralogy of Fallot, and patent foramen ovale.

Clinical trials85
Recruiting13
Drug concepts studied8
Synonyms12

Disease research snapshot

CureCurrent currently links 85 distinct registered clinical trials to congenital heart disease through its MONDO disease mappings. 13 of those studies have the registry status “recruiting” (15%). These are registry statuses, not availability guarantees, study results or evidence of effectiveness.

The leading sponsor shown in this linked dataset is National Heart, Lung, and Blood Institute (NHLBI), associated with 5 distinct linked trials. This is a count of records, not a ranking of the sponsor's scientific quality.

The highest-count mapped research city in the current result is New York, United States. Only site locations available in the published registry projection are counted; some trial sites may be missing or outdated.

The most frequently mapped drug concept in the current linked trials is enalapril (2 distinct trials). This describes what has been studied, not a recommended treatment.

Numbers are derived from CureCurrent's current ClinicalTrials.gov projection and conservative MONDO/RxNorm mappings. See sources, counting rules and limitations and verify eligibility or clinical findings with the original study record.

Research intelligence

Directly mapped studies only · unique clinical trials

Current registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.

Medications under investigation

Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.

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MONDO disease family

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Recruiting studies by city

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Trial status

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Trial phase

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Study start year

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Investigated drug interventions

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Clinical trials

40 shown
SGLT2 Inhibition With Empagliflozin in Fontan Circulatory FailureNCT06955260 · 2026-05-29
RECRUITING
Longitudinal Validation of CIRC TechnologiesNCT07081711 · 2026-05-06
RECRUITING
Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp SystemNCT06080074 · 2025-04-15
RECRUITING
NeoDoppler: New Ultrasound Technology for Continuous Monitoring of Cerebral Circulation PilotNCT06646250 · 2024-10-20
RECRUITING
iPSC Biobank of Biomarkers Diversity in Cardiovascular DiseaseNCT06371937 · 2024-05-01
RECRUITING
Preeclampsia and Fetal Heart Malformations: Looking to Maternal HeartNCT07092644 · 2023-11-16
RECRUITING
Autologous Induced Pluripotent Stem Cells of Cardiac Lineage for Congenital Heart DiseaseNCT05647213 · 2023-02-03
RECRUITING
Adult Congenital Heart Disease International EValuation of the Effectiveness of SGLT2i RegistryNCT06932081 · 2023-01-01
RECRUITING
Development of CIRC TechnologiesNCT05654272 · 2022-09-09
RECRUITING
Domestication and Implementation of the PEN-Plus Clinical Model in the Zambian Health SystemNCT07753681 · 2022-08-08
RECRUITING
Stress Echo 2030: the Novel ABCDE-(FGLPR) Protocol to Define the Future of ImagingNCT05081115 · 2021-04-01
RECRUITING
The PAtients pResenTing With COngenital HeaRt DIseAse Register (ARTORIA-R)NCT04848844 · 2020-09-02
RECRUITING
Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt LesionsNCT02691689 · 2015-11-01
RECRUITING
TORCH-LATAM-003: Regional Advanced-Therapy Pathways for Congenital Heart DiseaseNCT07837024 · 2027-03-30
NOT_YET_RECRUITING
Wearable Assessment of Thoracic, Cardiac Health and Exercise Performance Trial ProspectiveNCT07663799 · 2026-08-01
NOT_YET_RECRUITING
Comparison of Two Gait Re-training Modalities During a Cardiac Rehabilitation Stay: Benefit of Orienteering WalkingNCT06941597 · 2025-04-28
COMPLETED
The Influence of Probiotics on Metabolome and Heart Rate Variability in Heart Failure of Structure Heart DiseaseNCT06872320 · 2025-03-28
ACTIVE_NOT_RECRUITING
Wearable Assessment of Thoracic, Cardiac Health and Exercise Performance TrialNCT06671171 · 2025-02-03
COMPLETED
Congenital Heart DefectsNCT06124443 · 2024-12-01
UNKNOWN
IntelliStent for Pulmonary Flow Adjustment in Congenital Heart Disease and Dilated CardiomyopathyNCT06072937 · 2024-06-04
UNKNOWN
Cardiac Rehabilitation for Young PeopleNCT05968521 · 2024-03-04
UNKNOWN
The Effects of the Otago Exercise ProgramNCT06172790 · 2024-02-01
UNKNOWN
Prevalence of Obesity Among Adult Patients With Congenital Heart Disease: a Population-based StudyNCT06661434 · 2023-09-01
COMPLETED
" Evaluation of Safety and Efficacy of Empagliflozin and Sacubitril/Valsartan for CHF With Reduced Ejection Fraction in ACHD "NCT05580510 · 2023-02-06
UNKNOWN
Cardiac Resynchronization Therapy in Adult Congenital Heart Disease With Systemic Right Ventricle: RIGHT-CRTNCT05524324 · 2022-11-15
COMPLETED
EXCOR Active Driving System for the EXCOR Pediatric VAD IDE StudyNCT05610787 · 2022-11-14
ENROLLING_BY_INVITATION
Efficacy of Triple-Combination Therapy in Severe PAH-CHDNCT06196801 · 2022-06-17
ACTIVE_NOT_RECRUITING
Gender Difference in NET Activation in Patients With Congenital Heart Disease and Heart FailureNCT05263843 · 2022-02-22
UNKNOWN
Virtual Remote Physiological Monitoring Program of Children With Heart DiseaseNCT05034354 · 2022-02-08
COMPLETED
The Application of a Wireless Sensor Technology for Vital Statistics in CHILDREN AND ADULTSNCT01845506 · 2021-12-01
UNKNOWN
Transcatheter Pulmonary Valve Implantation With SAPIEN 3 ValveNCT05264181 · 2021-09-01
UNKNOWN
The Level of sST2 in Pediatric Heart FailureNCT06347510 · 2021-08-16
COMPLETED
Evaluation of the Prevalence and Clinical Manifestation of SARS-CoV-2 Infection in a Population of Adult and Pediatric Patients With Congenital Heart DiseaseNCT06784687 · 2021-08-01
COMPLETED
Congenital Heart Anomaly Risk in Maternal Enteroviral Infection and DiabetesNCT04769167 · 2021-02-01
COMPLETED
Global Utilization And Registry Database for Improved heArt preservatioNNCT04141605 · 2020-02-14
ENROLLING_BY_INVITATION
MRI to Predict Rejection and Failure in Transplant and Cardiomyopathy PatientsNCT03822442 · 2019-12-10
COMPLETED
eHealth as an Aid for Facilitating and Supporting Self-management in Families With Long-term Childhood IllnessNCT04150120 · 2019-10-15
COMPLETED
Evaluating Right Ventricular (RV) Size and Function Using the Upper Valley RV Algorithm and Novel Imaging ModalitiesNCT03935178 · 2019-08-05
TERMINATED
A Comparative Study of Three Modes of Ventilation During CPB in Pediatrics With Pulmonary Hypertension Undergoing Congenital Heart SurgeriesNCT04262037 · 2019-08-01
UNKNOWN
GoalKeeper: Intelligent Information Sharing for Children With Medical ComplexityNCT03620071 · 2019-04-19
COMPLETED

Leading sponsors

How to interpret this record

CureCurrent links normalized diseases, medicines, registry study labels, sponsors and research sites. A link is not the same as a finding of clinical effectiveness. Our research guides explain how to compare studies, decode RxNorm identities, and avoid over-interpreting site and trial counts. See the published database coverage for mapping completeness.

Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.