Disease & disorder
Down syndrome
MONDO:0008608
Down syndrome is a chromosomal abnormality caused by the presence of a third (partial or total) copy of the chromosome 21 genetic material and that is characterized by variable intellectual disability, muscular hypotonia, and joint laxity, often associated with a characteristic facial dysmorphism and various anomalies such as cardiac, gastrointestinal, or endocrine defects.
Research intelligence
Directly mapped studies only · unique clinical trialsCurrent registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.
Medications under investigation
Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.
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MONDO disease family
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Recruiting studies by city
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Trial status
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Trial phase
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Study start year
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Investigated drug interventions
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Clinical trials
36 shownLEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down SyndromeNCT07234695 · 2025-12-22
RECRUITINGAerobic Exercise With and Without Low Calorie Diet on Adiposity and BMI of Down SyndromeNCT06943170 · 2025-02-15
RECRUITINGPhysical Activity and Community EmPOWERment ProjectNCT06740162 · 2025-01-10
RECRUITINGBrain Outcomes With Lifestyle Change in Down SyndromeNCT05985486 · 2024-10-22
RECRUITINGGamma Frequency Stimulation in Individuals With Down SyndromeNCT05196984 · 2021-12-06
RECRUITINGCholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and CognitionNCT05231798 · 2021-08-19
RECRUITINGTrial-Ready Cohort-Down Syndrome (TRC-DS)NCT04165109 · 2021-06-07
RECRUITINGGnRH Therapy on Cognition in Down SyndromeNCT04390646 · 2020-08-27
RECRUITINGPharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)NCT04278404 · 2020-03-05
RECRUITINGRetinal Imaging in Neurodegenerative DiseaseNCT03233646 · 2017-07-20
RECRUITINGEscalating Doses of Memantine in Down Syndrome (MEDS-123)NCT07531940 · 2026-10-14
NOT_YET_RECRUITINGHomeGrown: A Family-based Lifestyle Intervention to Support Healthy Development of Young Children With Down SyndromeNCT07296861 · 2026-04-16
ACTIVE_NOT_RECRUITINGHero: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) and Pharmacodynamics (PD) of ION269 in Participants With Down Syndrome (DS) at Risk for Alzheimer's Disease (AD)NCT06673069 · 2024-12-20
TERMINATEDInfectious and Non-infectious Lower Respiratory Diseases in Children With Down Syndrome Followed in Pediatric Pulmonology Consultations in Ile-de-FranceNCT06336577 · 2024-03-28
COMPLETEDLeucettinib-21 First-in-Human Phase 1 in Healthy Volunteers and Subjects With Down Syndrome and Alzheimer's DiseaseNCT06206824 · 2024-01-18
COMPLETEDLIFE-DSR-Biomarker Sub-study of Biomarkers in Down Syndrome Related Alzheimer's Disease (DS-AD)NCT06860373 · 2023-06-27
TERMINATEDThe Epidemiology, Management and Comorbidities in Alopecia Areata in Czech RepublicNCT05098600 · 2021-10-15
COMPLETEDA Study of ACI-24 in Adults With Down SyndromeNCT04373616 · 2021-10-01
WITHDRAWNElucidating Age-related Comorbidity Patterns in Down Syndrome (DS)NCT05310552 · 2021-06-10
COMPLETEDThe Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults With Down SyndromeNCT04048759 · 2020-01-21
COMPLETEDCohort Study of Adult Patients With Down Syndrome at Risk of Developing Alzheimer's Disease (TriAL21)NCT03901261 · 2019-04-26
UNKNOWNParent and Infant Inter(X)Action Intervention (PIXI)NCT03836300 · 2018-11-30
ENROLLING_BY_INVITATIONQoL and Stress in Parents of Children With Developmental Disabilities and Chronic DiseaseNCT03602378 · 2018-04-02
UNKNOWNRelationship Between Down Syndrome (DS) and Alzheimer's Disease (AD)NCT02759887 · 2016-11-01
COMPLETEDRocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping StudyNCT02612376 · 2016-02-01
TERMINATEDWeight Management for Adolescents With IDDNCT02561754 · 2015-03-01
COMPLETEDDown Syndrome Biomarker Initiative (DSBI)NCT02141971 · 2013-06-01
COMPLETEDNicotine Treatment of Cognitive Decline in Down SyndromeNCT01778946 · 2013-04-01
COMPLETEDDown Syndrome Metabolic Health StudyNCT01821300 · 2013-02-01
COMPLETEDAmyloid Plaque and Tangle Imaging in Alzheimer's Disease and Down SyndromeNCT00965835 · 2009-08-01
UNKNOWNNatural History of Amyloid Deposition in Adults With Down SyndromeNCT01303133 · 2009-08-01
COMPLETEDGlucose Metabolic, Amyloid, and Tau Brain Imaging in Down Syndrome and DementiaNCT00966017 · 2009-07-01
UNKNOWNParent Supported Weight Reduction in Down SyndromeNCT01256112 · 2006-09-01
COMPLETEDVitamin E in Aging Persons With Down SyndromeNCT00056329 · 2002-04-01
UNKNOWNMulticenter Vitamin E Trial in Aging Persons With Down SyndromeNCT01594346 · 2000-09-01
COMPLETEDBrain Study of Patients With Frontal Lobe Dementia and Parkinsonian DisordersNCT00001178 · 1981-01-19
TERMINATEDDrugs being studied
Research locations
Kansas CityKansas, United States6MadisonWisconsin, United States4NashvilleTennessee, United States4PhoenixArizona, United States4AuroraColorado, United States3BarcelonaSpain3Chapel HillNorth Carolina, United States3IndianapolisIndiana, United States3LexingtonKentucky, United States3Los AngelesCalifornia, United States3BostonMassachusetts, United States2ChicagoIllinois, United States2
Leading sponsors
University of Kansas Medical Center3Duke University2National Institute on Aging (NIA)2New York State Institute for Basic Research2Vanderbilt University Medical Center2AC Immune SA1Centre Hospitalier Sud Francilien1Children's Hospital of Philadelphia1Faculty Hospital Kralovske Vinohrady1Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau1Institut Jerome Lejeune1Ionis Pharmaceuticals, Inc.1King's College London1LuMind IDSC Foundation1Massachusetts Institute of Technology1
Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.