Disease & disorder
histoplasmosis
MONDO:0018312
A disease caused by the fungus Histoplasma capsulatum. It primarily affects the lungs but can also occur as a disseminated disease that affects additional organs. The acute respiratory disease has symptoms similar to those of a cold or flu and it usually resolves without treatment in healthy individuals. The disseminated form is generally fatal if untreated.
Research intelligence
Directly mapped studies only · unique clinical trialsCurrent registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.
Medications under investigation
Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.
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MONDO disease family
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Recruiting studies by city
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Trial status
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Investigated drug interventions
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Clinical trials
8 shownRandomized Trial of Liposomal Amphotericin B for Histoplasmosis in AIDS PatientsNCT04059770 · 2020-02-14
COMPLETEDAdditive Benefit of the Urine LAM Test to Current TB Diagnostics in HIV Positive Adults in Panama City, PanamaNCT02911740 · 2017-11-01
WITHDRAWNA Study of Itraconazole in the Treatment and Prevention of Histoplasmosis, a Fungal Infection, in Patients With AIDSNCT00000975
COMPLETEDPilot Study to Determine the Feasibility of Fluconazole for Induction Treatment and Suppression of Relapse of Histoplasmosis in Patients With the Acquired Immunodeficiency SyndromeNCT00000627
COMPLETEDA Study of Itraconazole in Preventing the Return of Histoplasmosis, a Fungal Infection, in Patients With AIDSNCT00000992
COMPLETEDWithdrawal of Antifungal Treatment for Histoplasmosis in Patients After Improved Immune Response to Anti-HIV DrugsNCT00006316
COMPLETEDA Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or HistoplasmosisNCT00002159
COMPLETEDA Study of Itraconazole in the Prevention of Histoplasmosis, a Fungal Infection, in HIV-Infected PatientsNCT00002438
COMPLETEDDrugs being studied
Research locations
IndianapolisIndiana, United States6Los AngelesCalifornia, United States4New YorkNew York, United States4ChicagoIllinois, United States3CincinnatiOhio, United States3ColumbusOhio, United States3Kansas CityMissouri, United States3St LouisMissouri, United States3AtlantaGeorgia, United States2BirminghamAlabama, United States2New OrleansLouisiana, United States2PittsburghPennsylvania, United States2
Leading sponsors
Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.