Drug & intervention
fluconazole
RxCUI 4450
RxNorm ingredient and formulation relationships
Source-verified product relationships. Every strength, delivery form and RxCUI remains a separate clinical concept.
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Background context
Fluconazole
Fluconazole, sold under the brand name Diflucan among others, is an antifungal medication used for a number of fungal infections. These include candidiasis, blastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, dermatophytosis, and tinea versicolor. It is also used to prevent candidiasis in those who are at high risk such as following organ transplantation, low birth weight babies, and those with low blood neutrophil counts. It is given either by mouth or by injection into a vein.
Background only. Canonical identity remains RxNorm; clinical-trial relationships come from ClinicalTrials.gov.Clinical trials
40 shownClinical Study of ABCD in the Treatment of Cryptococcal MeningitisNCT05471063 · 2022-08-22
UNKNOWNCryptococcal Antigen Screening Plus SertralineNCT03002012 · 2017-11-15
TERMINATEDTreatment With Tamoxifen in Cryptococcal MeningitisNCT03112031 · 2017-10-10
COMPLETEDVietnam Cryptococcal Retention in Care Study Version 1.0NCT02334670 · 2015-08-14
UNKNOWNA Study Of PF-06647020 For Adult Patients With Advanced Solid TumorsNCT02222922 · 2014-10-17
COMPLETEDA Phase 1 Study to Evaluate the Effects of Fluconazole and Atorvastatin on the Pharmacokinetics of TAK-385 in Healthy SubjectsNCT02093390 · 2014-03-01
COMPLETEDSafety Study of Fluconazole in Combination With Flucytosine for the Treatment of Early Cryptococcal InfectionNCT01562132 · 2013-09-01
TERMINATEDReduction of EArly mortaLITY in HIV-infected Adults and Children Starting Antiretroviral TherapyNCT01825031 · 2013-06-01
COMPLETEDOperational Research for Cryptococcal Antigen ScreeningNCT01535469 · 2012-07-01
COMPLETEDStudy Evaluating Efficiency and Tolerance of High-dose Fluconazole Associated With Flucytosine as Induction Therapy for Cryptococcal Meningitis Associated With HIV in Sub-saharan AfricaNCT01715922 · 2012-05-01
UNKNOWNEffects of Urocortins on Forearm Arterial Blood Flow in Healthy Volunteers (Protocol 3)NCT01096706 · 2011-07-01
COMPLETEDStudy of Paroxetine and Fluconazole for the Treatment of HIV Associated Neurocognitive DisorderNCT01354314 · 2010-11-01
COMPLETEDHigh-Dose Fluconazole for the Treatment of Cryptococcal Meningitis in HIV-Infected IndividualsNCT00885703 · 2010-04-16
COMPLETEDDrug-Drug Interaction (DDI) w/Ketoconazole or FluconazoleNCT00860275 · 2009-04-01
COMPLETEDSingle Dose Versus Two Weeks Course of Fluconazole in the Treatment of Oropharyngeal Candidiasis in HIV Infected Individuals in TanzaniaNCT00553137 · 2006-11-01
COMPLETEDEarly Versus Delayed Antiretroviral Therapy (ART) in the Treatment of Cryptococcal Meningitis in AfricaNCT00830856 · 2006-10-01
COMPLETEDAmphotericin Alone or in Combination With Fluconazole for AIDS-Associated MeningitisNCT00145249 · 2005-05-01
COMPLETEDDiabetes Mellitus and Vulvovaginal CandidiasisNCT00353561 · 2004-06-01
COMPLETEDEffects of Nevirapine on the Steady State Pharmacokinetics of Fluconazole in HIV Positive PatientsNCT02181946 · 2001-05-01
COMPLETEDSafety and Antifungal Activity of Recombinant Interferon-Gamma 1b (rIFN-Gamma 1b) Given With Standard Therapy in Patients With Cryptococcal MeningitisNCT00012467 · 2000-01-01
COMPLETEDItraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow TransplantationNCT00003883 · 1998-10-01
COMPLETEDSafety and Effectiveness of Fluconazole Versus SCH 56592 to Treat Thrush in HIV-Positive PatientsNCT00002446 · 1998-08-01
COMPLETEDFluconazole Prophylaxis of Thrush in AIDSNCT00001542 · 1996-07-01
COMPLETEDA Pilot Study of Fluconazole Plus Flucytosine for the Treatment of AIDS Patients With Acute Cryptococcal Meningitis.NCT00002113
COMPLETEDAn Open, Non-Comparative Study of Intravenous and Oral Fluconazole in the Treatment of Acute Cryptococcal MeningitisNCT00002077
COMPLETEDA Study of Fluconazole in the Prevention of Fungal Infections in HIV-Infected Patients Living in Areas Where Fungal Infections Are CommonNCT00002325
COMPLETEDNon-Comparative Study of Fluconazole in Patients With Serious Mycoses and Who Cannot Be Treated With Conventional Antifungal TherapyNCT00002038
COMPLETEDRandomized, Controlled, Double-Blind Study of Itraconazole Oral Solution Versus Fluconazole Tablets for the Treatment of Esophageal Candidiasis.NCT00002132
COMPLETEDA Comparison of Fluconazole and Ketoconazole in the Treatment of Fungal Infections of the Throat in Patients With Weakened Immune SystemsNCT00002304
COMPLETEDA Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients With AIDSNCT00002282
COMPLETEDOpen, Non-Comparative Study of Intravenous and Oral Fluconazole in the Treatment of Acute Cryptococcal MeningitisNCT00002040
COMPLETEDPilot Study of Oral Fluconazole in the Treatment of Acute Cryptococcal MeningitisNCT00002076
COMPLETEDA Randomized Study of Daily and Intermittent Prophylactic Regimens for the Prevention of Disseminated Mycobacterium Avium Complex (MAC) and Fungal Infections in HIV-Infected PatientsNCT00002122
COMPLETEDA Comparison of SCH 56592 and Fluconazole in the Treatment of Oropharyngeal Candidiasis (OPC) in HIV-Positive PatientsNCT00002399
COMPLETEDMulticenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Maintenance Treatment for the Prevention of Relapse of Cryptococcal Meningitis in Patients With Acquired Immunodeficiency SyndromeNCT00002074
COMPLETEDA Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients Who Have Not Had Success With Amphotericin BNCT00002306
COMPLETEDA Comparison of Fluconazole and Amphotericin B in the Treatment of Cryptococcal MeningitisNCT00002305
COMPLETEDA Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal MeningitisNCT00002068
COMPLETEDOpen, Non-Comparative Study of Fluconazole in Patients With Coccidioidal MeningitisNCT00002010
COMPLETEDA Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients With AIDSNCT00002294
COMPLETEDConditions being studied
HIV Infections36Meningitis, Cryptococcal16Cryptococcal Meningitis6Mycoses6Candidiasis5Candidiasis, Oral5Candidiasis, Esophageal4Cryptococcosis2Hiv2Meningitis2Acquired Immunodeficiency Syndrome1AIDS-Related Opportunistic Infections1Alzheimer Disease1Bacterial Infections1Cancer1Central Nervous System Fungal Infections1Central Nervous System Infections1Coccidioidomycosis1Cryptococcal Infection Disseminated1Cryptococcal Infections1
Research locations
New YorkNew York, United States18Los AngelesCalifornia, United States16ChicagoIllinois, United States13San FranciscoCalifornia, United States13PhiladelphiaPennsylvania, United States11Washington D.C.District of Columbia, United States11BaltimoreMaryland, United States10MiamiFlorida, United States10San AntonioTexas, United States10BostonMassachusetts, United States9DetroitMichigan, United States9The BronxNew York, United States9
Leading sponsors
Pfizer21National Institute of Allergy and Infectious Diseases (NIAID)12Schering-Plough2University of Minnesota2Anna Griffiths, MRC1ANRS, Emerging Infectious Diseases1Boehringer Ingelheim1Bristol-Myers Squibb1Fred Hutchinson Cancer Center1Indian Council of Medical Research1InterMune1Janssen Pharmaceuticals1Johns Hopkins University1Millennium Pharmaceuticals, Inc.1National Hospital for Tropical Diseases, Hanoi, Vietnam1
Drug identity and terminology: RxNorm. Trial relationships: ClinicalTrials.gov.