Disease & disorder

obsessive-compulsive disorder

MONDO:0008114

A disorder characterized by the presence of persistent and recurrent irrational thoughts (obsessions), resulting in marked anxiety and repetitive excessive behaviors (compulsions) as a way to try to decrease that anxiety.

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Synonyms4

Research intelligence

Directly mapped studies only · unique clinical trials

Current registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.

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Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.

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Background context

Obsessive–compulsive disorder

Obsessive–compulsive disorder (OCD) is a mental disorder in which an individual has intrusive thoughts (an obsession) and feels the need to perform certain behaviors (compulsions) repeatedly to relieve the distress caused by the obsession, to the extent where it impairs general function. OCD has been described since antiquity and has affected numerous notable historical and contemporary figures; understandings of it were historically rooted in religion and beliefs about demonic possession. Obsessions are persistent unwanted thoughts, mental images, or urges that generate feelings of anxiety, disgust, or discomfort. Some common obsessions include fear of contamination, obsession with symmetry, the fear of acting blasphemously, sexual obsessions, and the fear of possibly harming others or themselves. Compulsions are repetitive actions performed in response to obsessions to reduce anxiety, such as washing, checking, counting, reassurance seeking, and situational avoidance. Compulsions occur often and typically take up at least one hour per day, impairing one's quality of life. Compulsions temporarily relieve distress but reinforce obsessions over time. Many adults with OCD recognize their rituals as irrational yet continue them to reduce anxiety. For this reason, thoughts and behaviors in OCD are usually considered egodystonic (inconsistent with one's ideal self-image). The causes of OCD are multifactorial and not fully understood, involving genetic predisposition, environmental stressors such as childhood trauma, abnormalities in brain structure and neurotransmitter functi...

Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.

Drugs being studied

Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.