Disease & disorder

psychotic disorder

MONDO:0005485

An abnormal condition of the mind that involves a loss of contact with reality. People experiencing psychosis may exhibit personality changes and thought disorder. Depending on its severity, this may be accompanied by unusual or bizarre behavior, as well as difficulty with social interaction and impairment in carrying out daily life activities.

Clinical trials396
Recruiting65
Drug concepts studied20
Synonyms3

Research intelligence

Directly mapped studies only · unique clinical trials

Current registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.

Medications under investigation

Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.

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Background context

Psychosis

In psychopathology, psychosis ( ) is the inability to distinguish what is or is not real. Examples of psychotic symptoms are delusions, hallucinations, and disorganized or incoherent thoughts or speech. Psychosis is a description of a person's state or symptoms, rather than a specific mental illness, and it is not related to the personality construct of psychopathy. Common causes of chronic psychosis include schizophrenia or schizoaffective disorder, bipolar disorder, and brain damage (usually as a result of alcoholism). Acute psychosis can also be caused by severe distress, sleep deprivation, sensory deprivation, some medications, and drug use and withdrawal (including alcohol, cannabis, hallucinogens, and stimulants). Acute psychosis is termed primary if it results from a psychiatric condition and secondary if it is caused by another medical condition or drugs. The diagnosis of a mental-health condition requires excluding other potential causes. Tests can be administered to check whether psychosis is caused by central nervous system diseases, toxins, or other health problems. Treatment may include antipsychotic medication, psychotherapy, and social support. Early treatment appears to improve outcomes. Medications appear to have a moderate effect. Outcomes depend on the underlying cause. Psychosis is not well-understood at the neurological level, but dopamine (along with other neurotransmitters) is known to play an important role. In the United States about 3% of people develop psychosis at some point in their lives. Psychosis has been described as early as the 4th cent...

Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.

Clinical trials

40 shown
Stratification and Treatment in Early Psychosis Study - ENHANCENCT06778564 · 2026-09-01
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Cognitive Strategies in Early Psychosis 2NCT07263022 · 2026-07-17
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Multimodal Intervention to Support Hospital-to-Community Transition in Bipolar DisorderNCT07213492 · 2026-06-01
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The Mouth Matters in Mental Health Trial -2NCT07470437 · 2026-05-01
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Effects of Action-Based Cognitive Remediation on Substance Misuse in Early Phase PsychosisNCT07056894 · 2026-03-27
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A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5)NCT06947941 · 2026-03-25
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A Case Series of Culturally-adapted CBTp for Black People in the UKNCT07252206 · 2026-02-24
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Early Psychosis: Investigating CognitionNCT07196423 · 2026-02-09
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Changing Lives and Changing Outcomes-9 at Worcester Recovery Center and HospitalNCT07359157 · 2026-02-05
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Acceptability, Feasibility and Preliminary Outcomes of the Kiso Mind App for Outpatients With Schizophrenia Spectrum DisordersNCT07395206 · 2026-01-30
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Speech-based Assessment of Relapse Risk in People With PsychosisNCT07397975 · 2026-01-29
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Precision Brain Stimulation to Reduce Cannabis Craving in SchizophreniaNCT07196462 · 2026-01-15
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The Effect of Combined Brain Stimulation and Yoga for Improving Cognitive Function in PsychosisNCT07747181 · 2026-01-01
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Preliminary Efficacy of an mHealth Intervention in West AfricaNCT07276321 · 2025-11-03
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State Representation in Early Psychosis 2NCT07834203 · 2025-10-15
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Brain Stimulation to the Hippocampus in SchizophreniaNCT07010614 · 2025-10-01
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Deprescribing Antipsychotics: a Multiple Case StudyNCT07343193 · 2025-09-09
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Randomized Clinical Trial of iTEST: A Blended Intervention Targeting Introspective AccuracyNCT07098169 · 2025-09-01
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Immune Mechanisms of Antipsychotic Treatment ResponseNCT06687694 · 2025-08-06
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Mentalization Based Treatment (MBT) in Help Seeking Youths With a Clinical High-Risk Condition for Psychosis (CHR-P)NCT07093671 · 2025-08-01
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Study on the Use of Exergames to Support Older Adults With PsychosisNCT07060742 · 2025-06-09
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A Novel Blood Test as a Biomarker in Mental HealthNCT06856161 · 2025-03-25
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Cannabis Potency Effects on Brain White Matter in Early Phase PsychosisNCT07001878 · 2025-03-18
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Enhancing Rehabilitation for Veterans With Serious Mental IllnessNCT06586164 · 2025-02-25
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A Mental Health Services Engagement Program for Racial and Ethnic Minority Young AdultsNCT06508450 · 2024-12-18
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Virtual Reality and Artificial Intelligence in Treatment for Patients With PsychosisNCT06728241 · 2024-12-06
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Clozapine-related Immunodeficiency in Parkinsons DiseaseNCT06634641 · 2024-10-01
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Effects of a Long-term Exercise Training Program on the Functional Capacity and Health-related Quality of Life in Inpatients With Psychotic DisordersNCT07113119 · 2024-08-04
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Cerebellar Modulation of Cognition in PsychosisNCT06107764 · 2024-07-31
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Investigating the Effect of a Single-dose of Levetiracetam on Brain Function, Chemistry and Cognitive Performance in Psychosis RiskNCT06224530 · 2024-07-19
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Behavioural Development, Long-term Outcomes and Opportunities to Optimize Youth Mental Health TrajectoriesNCT06978452 · 2024-07-01
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Predicting Psychotic Relapse Using Speech-Based Early DetectionNCT06978894 · 2024-05-27
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A Probiotic Strategy for Antipsychotic-induced Metabolic DysfunctionNCT06729671 · 2024-05-16
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Culturally Adapted Psychosocial Interventions for Early Psychosis in a Low-resource SettingNCT05814913 · 2024-04-15
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Ketogenic and Nutritional Interventions for First Episode Bipolar DisorderNCT06221852 · 2024-03-12
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The Effectiveness of Individualized Imagery Scripts on Sleep, Psychosis, and Suicidality Among Inpatients With PsychosisNCT06194344 · 2024-03-05
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TOPUS - Testing an Implemented Intervention to Reduce Duration of Untreated PsychosisNCT07716969 · 2024-03-01
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Enhanced Coordinated Specialty Care for Early PsychosisNCT06071858 · 2024-02-01
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Study of Language Disorders and Interactions Between Mnesic Capabilities and Semantic Competencies in Patients With PsychosisNCT06036316 · 2024-01-23
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HYEEG Discourse in Psychosis: A Neurobehavioural StudyNCT06978803 · 2024-01-16
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Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.