Drug & intervention

magnesium

RxCUI 6574

Clinical trials0
Recruiting0
Related conditions0
Synonyms1

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Background context

Magnesium

Magnesium is a chemical element; it has symbol Mg and atomic number 12. It is a shiny gray metal having a low density, low melting point, and high chemical reactivity. Like the other alkaline earth metals (group 2 of the periodic table), it occurs naturally only in combination with other elements and almost always has an oxidation state of +2. It reacts readily with air to form a thin passivation coating of magnesium oxide that inhibits further corrosion of the metal. The free metal burns with a brilliant-white light. The metal is obtained mainly by electrolysis of magnesium salts obtained from brine. It is less dense than aluminium and is used primarily as a component in strong and lightweight alloys that contain aluminium. In the cosmos, magnesium is produced in large, aging stars by the sequential addition of three helium nuclei to a carbon nucleus. When such stars explode as supernovas, much of the magnesium is expelled into the interstellar medium, where it may recycle into new star systems. Magnesium ranks eighth in the abundance of elements in Earth's crust. It is the third-most-abundant element dissolved in seawater, after sodium and chlorine. This element is required for many core functions of cells in the human body and to some 300 enzymes. Magnesium ions interact with polyphosphate compounds such as ATP, DNA and RNA. Magnesium compounds are used medicinally as common laxatives and antacids (such as milk of magnesia), and to stabilize abnormal nerve excitation or blood vessel spasm in such conditions as eclampsia.

Background only. Canonical identity remains RxNorm; clinical-trial relationships come from ClinicalTrials.gov.

Conditions being studied

Drug identity and terminology: RxNorm. Trial relationships: ClinicalTrials.gov.