Drug & intervention

melphalan

RxCUI 6718

Clinical trials28
Recruiting2
Related conditions20
Synonyms1

RxNorm ingredient and formulation relationships

Source-verified product relationships. Every strength, delivery form and RxCUI remains a separate clinical concept.

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Background context

Melphalan

Melphalan, sold under the brand name Alkeran among others, is a chemotherapy medication used to treat multiple myeloma; malignant lymphoma; lymphoblastic and myeloblastic leukemia; childhood neuroblastoma; ovarian cancer; mammary adenocarcinoma; and uveal melanoma. It is taken by mouth or by injection into a vein. Common side effects include nausea and bone marrow suppression. Other severe side effects may include anaphylaxis and the development of other cancers. Use during pregnancy may result in harm to the fetus. Melphalan belongs to the class of nitrogen mustard alkylating agents. It works by interfering with the creation of DNA and RNA. Melphalan was approved for medical use in the United States in 1964. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication.

Read on Wikipedia ↗ Wikidata Q2298283 ↗
Background only. Canonical identity remains RxNorm; clinical-trial relationships come from ClinicalTrials.gov.

Clinical trials

28 shown
SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem CellsNCT04150042 · 2021-01-13
RECRUITING
Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCTNCT01962415 · 2014-02-04
RECRUITING
Umbilical Cord Blood Transplant With Added Sugar and Chemotherapy and Radiation Therapy in Treating Patients With Leukemia or LymphomaNCT03096782 · 2017-10-13
COMPLETED
Phase 1 Study of Tremelimumab, Durvalumab, High-dose Chemotherapy, + Autologous Stem Cell TransplantNCT02716805 · 2016-12-13
TERMINATED
Gene Therapy in Treating Patients With Human Immunodeficiency Virus-Related Lymphoma Receiving Stem Cell TransplantNCT02797470 · 2016-06-23
ACTIVE_NOT_RECRUITING
Genetically Modified Peripheral Blood Stem Cell Transplant in Treating Patients With HIV-Associated Non-Hodgkin or Hodgkin LymphomaNCT01769911 · 2015-02-01
WITHDRAWN
CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell TransplantNCT02061800 · 2013-06-03
UNKNOWN
A Phase II Study Evaluating Intravenous Melphalan With Autologous Whole Blood Stem Cell Transplantation Over Three Cycles In Patients With Castration-Resistant Prostate Cancer (MEL-CAP)NCT01907009 · 2013-01-01
TERMINATED
Cord Blood Fucosylation to Enhance Homing and Engraftment in Patients With Hematologic MalignanciesNCT01471067 · 2012-07-13
COMPLETED
Autologous Transplant in HIV Patients (BMT CTN 0803)NCT01141712 · 2010-04-01
COMPLETED
Bortezomib and Dexamethasone Followed by High-Dose Melphalan and Stem Cell Transplantation for Primary (AL) AmyloidosisNCT01083316 · 2009-09-01
COMPLETED
Autologous Stem Cell Transplant for Neurologic Autoimmune DiseasesNCT00716066 · 2008-06-01
ACTIVE_NOT_RECRUITING
Allogeneic Hematopoietic Stem Cell Transplantation With Bevacizumab for Advanced Solid TumorNCT00523809 · 2007-08-01
TERMINATED
Combination Chemotherapy With or Without Trastuzumab Followed By an Autologous Stem Cell Transplant and Radiation Therapy in Treating Patients With Stage III or Stage IV Breast CancerNCT00182793 · 2005-07-01
COMPLETED
Hepatic Arterial Infusion of Melphalan With Hepatic Perfusion in Treating Patients With Unresectable Liver CancerNCT00096083 · 2004-09-01
COMPLETED
Allogeneic Stem Cell Transplant After ATG, High-Dose Melphalan, and Fludarabine for Patients With Breast CancerNCT00074269 · 2003-07-01
TERMINATED
Chemotherapy Plus Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Recurrent or Refractory Solid TumorsNCT00003899 · 1999-01-01
COMPLETED
Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Metastatic Prostate CancerNCT00003400 · 1998-09-01
COMPLETED
Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Stage II or Stage IIIA Breast CancerNCT00003972 · 1998-07-01
COMPLETED
Antiviral Therapy Plus Either Peripheral Stem Cell or Umbilical Cord Blood Transplantation in Treating Patients Who Are HIV Positive and Have Hematologic CancerNCT00003435 · 1998-05-01
WITHDRAWN
Mini-Allogeneic Peripheral Blood Progenitor Cell Transplantation For Recurrent or Metastatic Breast CancerNCT00429572 · 1998-01-01
COMPLETED
Phase I/II Study of Escalating-Dose Melphalan w/Autologous SCS & Amifostine CytoprotectNCT00003425 · 1997-12-01
COMPLETED
Combination Chemotherapy and Peripheral Blood Stem Cell Transplant Followed By Aldesleukin and Sargramostim in Treating Patients With Inflammatory Stage IIIB or Metastatic Stage IV Breast CancerNCT00003199 · 1997-11-01
COMPLETED
High-Dose Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Recurrent or Refractory Metastatic Breast CancerNCT00003392 · 1997-09-01
COMPLETED
Chemotherapy and Stem Cell Transplantation in Treating Patients With Stage IIIB Breast CancerNCT00003042 · 1997-05-30
COMPLETED
Repeated Bone Marrow Transplantation in Treating Women With Advanced Breast CancerNCT00003086 · 1997-03-01
TERMINATED
Sequential High-Dose Chemotherapy and Stem Cell Transplantation in Treating Patients With Chemotherapy-Sensitive Metastatic Breast CancerNCT00002680 · 1994-02-01
COMPLETED
High-Dose Chemotherapy, Total-Body Irradiation, and Autologous Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Hematologic Cancer or Solid TumorsNCT00060255 · 1991-12-01
COMPLETED

Conditions being studied

Breast Cancer11Lymphoma5Leukemia4Unspecified Adult Solid Tumor, Protocol Specific3Ovarian Cancer2Recurrent Adult Hodgkin Lymphoma2Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive1Acute Biphenotypic Leukemia1Acute Leukemia1Acute Lymphoblastic Leukemia1Acute Lymphoblastic Leukemia (ALL)1Acute Lymphoblastic Leukemia in Remission1Acute Myelogenous Leukemia (AML)1Acute Myeloid Leukemia1Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome1Adenocarcinoma of the Breast1Adult Nasal Type Extranodal NK/T-cell Lymphoma1AIDS-related Diffuse Large Cell Lymphoma1AIDS-related Diffuse Mixed Cell Lymphoma1AIDS-related Diffuse Small Cleaved Cell Lymphoma1

Drug identity and terminology: RxNorm. Trial relationships: ClinicalTrials.gov.