Drug & intervention
tremelimumab
RxCUI 2619313
RxNorm ingredient and formulation relationships
Source-verified product relationships. Every strength, delivery form and RxCUI remains a separate clinical concept.
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Clinical trials
40 shownA Phase I Dose Escalation and Dose Expansion Study to Investigate the Pharmacokinetics and Safety of Subcutaneous DurvalumabNCT07391670 · 2026-03-31
RECRUITINGTargeting Driver Oncogenes With a Peptide Vaccine Plus Durvalumab and Tremelimumab for Patients With Biliary Tract Cancers (BTC)NCT06564623 · 2025-05-27
RECRUITINGAdaptive ctDNA-Based Personalization of Treatment During Consolidation Therapy in NSCLCNCT04585490 · 2021-08-25
RECRUITINGDurvalumab and Tremelimumab in Combination With Chemotherapy in HIV-infected Patients With Non-small Cell Lung CancerNCT04499053 · 2020-12-09
RECRUITINGA Study to Investigate the Efficacy of Durvalumab Plus Tremelimumab in Combination With Chemotherapy Compared With Pembrolizumab in Combination With Chemotherapy in Metastatic NSCLC Patients With Non-squamous Histology Who Have Mutations and/or Co-mutations in STK11, KEAP1, or KRASNCT06008093 · 2024-04-04
ACTIVE_NOT_RECRUITINGStudy of Durvalumab + Tremelimumab in NSCLC Patients After Adjuvant TreatmentNCT04625699 · 2022-12-01
WITHDRAWN......SMARTEST Trial......NCT05380713 · 2022-05-03
COMPLETEDDurvalumab (MEDI4736) and Tremelimumab for Hepatocellular Carcinoma in Patients Listed for a Liver TransplantNCT05027425 · 2021-12-07
TERMINATEDBasket Trial for Combination Therapy With Durvalumab (Anti-PDL1) (MEDI4736) and Tremelimumab (Anti-CTLA4) in Patients With Metastatic Solid TumorsNCT03982173 · 2020-09-01
WITHDRAWNMicrobiome Immunotherapy Toxicity and Response EvaluationNCT04107168 · 2020-07-08
UNKNOWNImmunotherapy, Chemotherapy, Radiotherapy and Surgery for Synchronous Oligo-metastatic NSCLCNCT03965468 · 2019-11-19
ACTIVE_NOT_RECRUITINGCTLA-4 /PD-L1 Blockade Following Transarterial Chemoembolization (DEB-TACE) in Patients With Intermediate Stage of HCC (Hepatocellular Carcinoma) Using Durvalumab and TremelimumabNCT03638141 · 2019-10-02
COMPLETEDRadiotherapy and Durvalumab/Durvalumab Combo (Tremelimumab/Olaparid) for Small Cell Lung CancerNCT03923270 · 2019-06-06
ACTIVE_NOT_RECRUITINGAssess the Safety of Immunotherapy Induction With Tremelimumab and Durvalumab Prior to Chemoradiotherapy and/or Resection in the TreatmentNCT04287894 · 2018-12-28
TERMINATEDA Study Comparing Immunotherapy With Chemotherapy in the Treatment of Elderly Patients With Advanced NSCLC (MILES-5)NCT03975114 · 2018-12-20
UNKNOWNGSK3359609 Plus Tremelimumab for the Treatment of Advanced Solid TumorsNCT03693612 · 2018-11-26
COMPLETEDCombination of Durvalumab and Tremelimumab as Maintenance Treatment in Patients With Non Squamous and Squamous (NSCLC)NCT03319316 · 2018-11-01
WITHDRAWNNon Small Cell Lung Cancer Trial of Durvalumab and Tremelimumab in Advanced Epidermal Growth Factor Receptor (EGFR) Mutant Disease.NCT03994393 · 2018-10-23
UNKNOWNStudy of Durvalumab + Tremelimumab, Durvalumab, and Placebo in Limited Stage Small-Cell Lung Cancer in Patients Who Have Not Progressed Following Concurrent Chemoradiation TherapyNCT03703297 · 2018-09-27
ACTIVE_NOT_RECRUITINGImmunotherapy in Combination With Chemoradiation in Patients With Advanced Solid TumorsNCT03509012 · 2018-05-02
COMPLETEDPhase Ib Study of Stereotactic Body Radiotherapy (SBRT) in Oligometastatic Non-small Lung Cancer (NSCLC) With Dual Immune Checkpoint InhibitionNCT03275597 · 2018-02-20
TERMINATEDPhase 1/2 Study of Combination Immunotherapy and Messenger Ribonucleic Acid (mRNA) Vaccine in Subjects With NSCLCNCT03164772 · 2017-12-20
COMPLETEDSGI-110 Plus Durvalumab/Tremelimumab in SCLCNCT03085849 · 2017-12-15
COMPLETEDNeoadjuvant Immunoradiation for Resectable Non-Small Cell Lung CancerNCT03237377 · 2017-12-12
TERMINATEDA Trial of Durvalumab and Tremelimumab in Combination With SBRT in Patients With Metastatic CancerNCT03212469 · 2017-06-20
COMPLETEDStudy of Durvalumab + Tremelimumab With Chemotherapy or Durvalumab With Chemotherapy or Chemotherapy Alone for Patients With Lung Cancer (POSEIDON).NCT03164616 · 2017-06-01
ACTIVE_NOT_RECRUITINGDurvalumab (MEDI4736) Plus Tremelimumab for Advanced Neuroendocrine Neoplasms of Gastroenteropancreatic or Lung OriginNCT03095274 · 2017-04-11
COMPLETEDDurvalumab and Tremelimumab ± Platinum-Based Chemotherapy in Patients With Metastatic Squamous or Non-Squamous NSCLCNCT03057106 · 2017-03-28
ACTIVE_NOT_RECRUITINGDurvalumab ± Tremelimumab in Combination With Platinum Based Chemotherapy in Untreated Extensive-Stage Small Cell Lung Cancer (CASPIAN)NCT03043872 · 2017-03-27
ACTIVE_NOT_RECRUITINGDurvalumab and Tremelimumab for Adjuvant Therapy of Resected NSCLCNCT03130764 · 2017-03-01
WITHDRAWNA Study of Tremelimumab and IV Durvalumab Plus Poly-ICLC in Subjects With Biopsy-accessible CancersNCT02643303 · 2016-12-28
COMPLETEDDurvalumab With or Without Tremelimumab in Metastatic Castration Resistant Prostate CancerNCT02788773 · 2016-12-15
COMPLETEDPhase 1 Study of Tremelimumab, Durvalumab, High-dose Chemotherapy, + Autologous Stem Cell TransplantNCT02716805 · 2016-12-13
TERMINATEDA Pilot Study of Combined Immune Checkpoint Inhibition in Combination With Ablative Therapies in Subjects With Hepatocellular Carcinoma (HCC) or Biliary Tract Carcinomas (BTC)NCT02821754 · 2016-07-05
COMPLETEDStudy of Anti-PD-L1 in Combination With Chemo(Radio)Therapy for Oesophageal CancerNCT02735239 · 2016-06-24
COMPLETEDTrial Of Hypofractionated Radiotherapy In Combination With MEDI4736 And Tremelimumab For Patients With Metastatic Melanoma And Lung, Breast And Pancreatic CancersNCT02639026 · 2016-01-26
COMPLETEDA Study to Assess the Safety, Tolerability and Anti-tumour Activity of Ascending Doses of Selumetinib in Combination With MEDI4736 and Selumetinib in Combination With MEDI4736 and Tremelimumab in Patients With Advanced Solid TumoursNCT02586987 · 2015-12-28
COMPLETEDBrain Irradiation and Tremelimumab in Metastatic Breast CancerNCT02563925 · 2015-09-18
COMPLETEDImmune-Modulated Study of Selected Small Molecules (Gefitinib, AZD9291, or Selumetinib + Docetaxel) or a 1st Immune-Mediated Therapy (IMT; Tremelimumab) With a Sequential Switch to a 2nd IMT (MEDI4736) in Patients With Locally Advanced or Metastatic Non-Small-Cell Lung CancerNCT02179671 · 2014-07-25
COMPLETEDTolerability and Efficacy of Tremelimumab in Combination With Gefitinib in NSCLC PatientsNCT02040064 · 2014-01-01
COMPLETEDConditions being studied
Non-small Cell Lung Cancer5Breast Cancer4Lung Cancer4Melanoma4Carcinoma, Non-Small-Cell Lung3Hepatocellular Carcinoma3Nsclc3Colorectal Cancer2Head and Neck Squamous Cell Carcinoma2Malignant Mesothelioma2Non Small Cell Lung Cancer2Prostate Cancer2Renal Cancer2Bile Duct Cancer1Biliary Tract Cancer1Biliary Tract Cancers1Biliary Tract Neoplasms1Bladder Cancer1Carcinoma, Non-Small Cell Lung1Carcinoma, Squamous Cell of Head and Neck1
Research locations
Leading sponsors
AstraZeneca8Ludwig Institute for Cancer Research5Gustave Roussy, Cancer Campus, Grand Paris3Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins3Azienda Ospedaliera Universitaria Senese2Canadian Cancer Trials Group2Catherine Shu2MedImmune LLC2Abramson Cancer Center at Penn Medicine1CCTU- Cancer Theme1Columbia University1ETOP IBCSG Partners Foundation1European Organisation for Research and Treatment of Cancer - EORTC1Georgetown University1GlaxoSmithKline1
Drug identity and terminology: RxNorm. Trial relationships: ClinicalTrials.gov.