Clinical trial

MS-SMART: Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial

NCT01910259

StatusCOMPLETED

Study typeINTERVENTIONAL

Start date2014-12-18

PhasePHASE2

Study timeline

Study start (actual)2014-12-18Date precision: day

Registry last updated2020-03-26

Observed by CureCurrent2026-10-07

Recorded dates are source observations, not predictions. Missing milestones are not estimated.

Conditions

Secondary Progressive Multiple Sclerosisunresolved

Interventions

AmilorideDRUG · verified · RxNorm: amiloride

RiluzoleDRUG · verified · RxNorm: riluzole

FluoxetineDRUG · verified · RxNorm: fluoxetine

Sponsors & collaborators

University College, Londonlead sponsor

Medical Research Councilcollaborator

National Institute for Health Research, United Kingdomcollaborator

National Multiple Sclerosis Societycollaborator

University of Edinburghcollaborator

Queen Mary University of Londoncollaborator

Keele Universitycollaborator

University of Sheffieldcollaborator

University of Leedscollaborator

University of Warwickcollaborator

Mapped research locations

LondonUnited Kingdom1 GlasgowUnited Kingdom1 NottinghamUnited Kingdom1 SheffieldUnited Kingdom1 LiverpoolUnited Kingdom1 EdinburghUnited Kingdom1 LeedsUnited Kingdom1 OxfordUnited Kingdom1

Registry source

Open the source record to verify current eligibility, contacts, locations and registry updates.

Open NCT01910259 on ClinicalTrials.gov ↗

Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.