Clinical trial

Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial

NCT03878524

Drugs and interventions used in this trial

56 registered

These interventions are listed by ClinicalTrials.gov. An RxNorm link indicates a mapped medicine record; the registry name alone is not proof of a specific branded formulation.

Search this trial's interventions

DRUG · Mapped RxNorm record Abemaciclib Normalized identity: abemaciclibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Abiraterone Normalized identity: abirateroneView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Afatinib Normalized identity: afatinibView linked drug · Find medicine records · Find other trials using this name

BIOLOGICAL · Unmapped registry intervention Bevacizumab Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Bicalutamide Normalized identity: bicalutamideView linked drug · Find medicine records · Find other trials using this name

PROCEDURE · Unmapped registry intervention Biospecimen Collection Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Bortezomib Normalized identity: bortezomibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Cabazitaxel Normalized identity: cabazitaxelView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Cabozantinib Normalized identity: cabozantinibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Capecitabine Normalized identity: capecitabineView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Carboplatin Normalized identity: carboplatinView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Celecoxib Normalized identity: celecoxibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Cobimetinib Normalized identity: cobimetinibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Copanlisib Normalized identity: copanlisibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Dabrafenib Normalized identity: dabrafenibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Dacomitinib Normalized identity: dacomitinibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Darolutamide Normalized identity: darolutamideView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Dasatinib Normalized identity: dasatinibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Doxorubicin Normalized identity: doxorubicinView linked drug · Find medicine records · Find other trials using this name

BIOLOGICAL · Unmapped registry intervention Durvalumab Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Enasidenib Normalized identity: enasidenibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Entrectinib Normalized identity: entrectinibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Enzalutamide Normalized identity: enzalutamideView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Erlotinib Normalized identity: erlotinibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Everolimus Normalized identity: everolimusView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Fluorouracil Normalized identity: fluorouracilView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Idelalisib Normalized identity: idelalisibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Imatinib Normalized identity: imatinibView linked drug · Find medicine records · Find other trials using this name

BIOLOGICAL · Unmapped registry intervention Ipilimumab Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Lenvatinib Normalized identity: lenvatinibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Leucovorin Normalized identity: leucovorinView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Lorlatinib Normalized identity: lorlatinibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Losartan Normalized identity: losartanView linked drug · Find medicine records · Find other trials using this name

DRUG · Unmapped registry intervention Nab-paclitaxel Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Neratinib Normalized identity: neratinibView linked drug · Find medicine records · Find other trials using this name

BIOLOGICAL · Unmapped registry intervention Nivolumab Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Olaparib Normalized identity: olaparibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Oxaliplatin Normalized identity: oxaliplatinView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Palbociclib Normalized identity: palbociclibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Panobinostat Normalized identity: panobinostatView linked drug · Find medicine records · Find other trials using this name

BIOLOGICAL · Unmapped registry intervention Pembrolizumab Find medicine records · Find other trials using this name

BIOLOGICAL · Unmapped registry intervention Pertuzumab Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Ponatinib Normalized identity: ponatinibView linked drug · Find medicine records · Find other trials using this name

OTHER · Unmapped registry intervention Quality-of-Life Assessment Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Regorafenib Normalized identity: regorafenibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Ruxolitinib Normalized identity: ruxolitinibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Sirolimus Normalized identity: sirolimusView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Sorafenib Normalized identity: sorafenibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Sunitinib Normalized identity: sunitinibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Trametinib Normalized identity: trametinibView linked drug · Find medicine records · Find other trials using this name

BIOLOGICAL · Unmapped registry intervention Trastuzumab Emtansine Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Tretinoin Normalized identity: tretinoinView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Vemurafenib Normalized identity: vemurafenibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Venetoclax Normalized identity: venetoclaxView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Vismodegib Normalized identity: vismodegibView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Vorinostat Normalized identity: vorinostatView linked drug · Find medicine records · Find other trials using this name

Study at a glance

Registry-backed

Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial

Design: INTERVENTIONAL · Status: TERMINATED · Phase: PHASE1

Read study objectives, eligibility and outcome measures at ClinicalTrials.gov

StatusTERMINATED

Study typeINTERVENTIONAL

Start date2020-04-01

PhasePHASE1

Conditions

Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positiveunresolved

Anatomic Stage IV Breast Cancer AJCC v8unresolved

Anemiaverified · MONDO: anemia

Ann Arbor Stage III Hodgkin Lymphomaunresolved

Ann Arbor Stage III Non-Hodgkin Lymphomaunresolved

Ann Arbor Stage IV Hodgkin Lymphomaunresolved

Ann Arbor Stage IV Non-Hodgkin Lymphomaunresolved

Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negativeverified · MONDO: atypical chronic myeloid leukemia, BCR-ABL1 negative

Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positiveverified · MONDO: blast phase chronic myelogenous leukemia, BCR-ABL1 positive

Castration-Resistant Prostate Carcinomaverified · MONDO: castration-resistant prostate carcinoma

Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positiveunresolved

Hematopoietic and Lymphoid System Neoplasmverified · MONDO: hematopoietic and lymphoid system neoplasm

Locally Advanced Pancreatic Adenocarcinomaunresolved

Metastatic Breast Carcinomaunresolved

Metastatic Malignant Solid Neoplasmunresolved

Metastatic Pancreatic Adenocarcinomaunresolved

Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosisunresolved

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiableunresolved

Primary Myelofibrosisverified · MONDO: primary myelofibrosis

Recurrent Acute Lymphoblastic Leukemiaunresolved

Recurrent Acute Myeloid Leukemiaunresolved

Recurrent Chronic Lymphocytic Leukemiaunresolved

Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positiveunresolved

Recurrent Hematologic Malignancyunresolved

Recurrent Hodgkin Lymphomaunresolved

Recurrent Myelodysplastic Syndromeunresolved

Recurrent Myelodysplastic/Myeloproliferative Neoplasmunresolved

Recurrent Myeloproliferative Neoplasmunresolved

Recurrent Non-Hodgkin Lymphomaunresolved

Recurrent Plasma Cell Myelomaunresolved

Recurrent Small Lymphocytic Lymphomaunresolved

Refractory Acute Lymphoblastic Leukemiaunresolved

Refractory Acute Myeloid Leukemiaunresolved

Refractory Chronic Lymphocytic Leukemiaunresolved

Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positiveunresolved

Refractory Chronic Myelomonocytic Leukemiaunresolved

Refractory Hematologic Malignancyverified · MONDO: refractory hematologic cancer

Refractory Hodgkin Lymphomaunresolved

Refractory Malignant Solid Neoplasmunresolved

Refractory Myelodysplastic Syndromeunresolved

Refractory Myelodysplastic/Myeloproliferative Neoplasmunresolved

Refractory Non-Hodgkin Lymphomaunresolved

Refractory Plasma Cell Myelomaunresolved

Refractory Primary Myelofibrosisunresolved

Refractory Small Lymphocytic Lymphomaunresolved

Stage II Pancreatic Cancer AJCC v8unresolved

Stage III Pancreatic Cancer AJCC v8unresolved

Stage IV Pancreatic Cancer AJCC v8unresolved

Stage IV Prostate Cancer AJCC v8unresolved

Unresectable Pancreatic Adenocarcinomaunresolved

Interventions

AbemaciclibDRUG · verified · RxNorm: abemaciclib

AbirateroneDRUG · verified · RxNorm: abiraterone

AfatinibDRUG · verified · RxNorm: afatinib

BevacizumabBIOLOGICAL

BicalutamideDRUG · verified · RxNorm: bicalutamide

Biospecimen CollectionPROCEDURE

BortezomibDRUG · verified · RxNorm: bortezomib

CabazitaxelDRUG · verified · RxNorm: cabazitaxel

CabozantinibDRUG · verified · RxNorm: cabozantinib

CapecitabineDRUG · verified · RxNorm: capecitabine

CarboplatinDRUG · verified · RxNorm: carboplatin

CelecoxibDRUG · verified · RxNorm: celecoxib

CobimetinibDRUG · verified · RxNorm: cobimetinib

CopanlisibDRUG · verified · RxNorm: copanlisib

DabrafenibDRUG · verified · RxNorm: dabrafenib

DacomitinibDRUG · verified · RxNorm: dacomitinib

DarolutamideDRUG · verified · RxNorm: darolutamide

DasatinibDRUG · verified · RxNorm: dasatinib

DoxorubicinDRUG · verified · RxNorm: doxorubicin

DurvalumabBIOLOGICAL

EnasidenibDRUG · verified · RxNorm: enasidenib

EntrectinibDRUG · verified · RxNorm: entrectinib

EnzalutamideDRUG · verified · RxNorm: enzalutamide

ErlotinibDRUG · verified · RxNorm: erlotinib

EverolimusDRUG · verified · RxNorm: everolimus

FluorouracilDRUG · verified · RxNorm: fluorouracil

IdelalisibDRUG · verified · RxNorm: idelalisib

ImatinibDRUG · verified · RxNorm: imatinib

IpilimumabBIOLOGICAL

LenvatinibDRUG · verified · RxNorm: lenvatinib

LeucovorinDRUG · verified · RxNorm: leucovorin

LorlatinibDRUG · verified · RxNorm: lorlatinib

LosartanDRUG · verified · RxNorm: losartan

Nab-paclitaxelDRUG

NeratinibDRUG · verified · RxNorm: neratinib

NivolumabBIOLOGICAL

OlaparibDRUG · verified · RxNorm: olaparib

OxaliplatinDRUG · verified · RxNorm: oxaliplatin

PalbociclibDRUG · verified · RxNorm: palbociclib

PanobinostatDRUG · verified · RxNorm: panobinostat

PembrolizumabBIOLOGICAL

PertuzumabBIOLOGICAL

PonatinibDRUG · verified · RxNorm: ponatinib

Quality-of-Life AssessmentOTHER

RegorafenibDRUG · verified · RxNorm: regorafenib

RuxolitinibDRUG · verified · RxNorm: ruxolitinib

SirolimusDRUG · verified · RxNorm: sirolimus

SorafenibDRUG · verified · RxNorm: sorafenib

SunitinibDRUG · verified · RxNorm: sunitinib

TrametinibDRUG · verified · RxNorm: trametinib

Trastuzumab EmtansineBIOLOGICAL

TretinoinDRUG · verified · RxNorm: tretinoin

VemurafenibDRUG · verified · RxNorm: vemurafenib

VenetoclaxDRUG · verified · RxNorm: venetoclax

VismodegibDRUG · verified · RxNorm: vismodegib

VorinostatDRUG · verified · RxNorm: vorinostat

Sponsors & collaborators

OHSU Knight Cancer Institutelead sponsor

Oregon Health and Science Universitycollaborator

Mapped research locations

PortlandOregon, United States1

Registry source

Open the source record to verify current eligibility, contacts, locations and registry updates.

Open NCT03878524 on ClinicalTrials.gov ↗

Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.