Drug & intervention
cobimetinib
RxCUI 1722365
RxNorm ingredient and formulation relationships
Source-verified product relationships. Every strength, delivery form and RxCUI remains a separate clinical concept.
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Clinical trials
17 shownDETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.NCT05768178 · 2023-03-01
RECRUITINGCobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic DisordersNCT04079179 · 2021-04-19
RECRUITINGA Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)NCT04302025 · 2020-11-06
RECRUITINGSMMART Adaptive Clinical Treatment (ACT) TrialNCT05238831 · 2023-01-30
WITHDRAWNThe Rome Trial From Histology to Target: the Road to Personalize Target Therapy and ImmunotherapyNCT04591431 · 2020-10-07
UNKNOWNSafety and Tolerability of ABM-1310 in Patients With Advanced Solid TumorsNCT04190628 · 2020-06-16
TERMINATEDSerial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME TrialNCT03878524 · 2020-04-01
TERMINATEDDose-Esc/Exp RMC4630 & Cobi in Relapsed/Refractory Solid Tumors & RMC4630& Osi in EGFR+ Locally Adv/Meta NSCLCNCT03989115 · 2019-07-02
COMPLETEDAtezolizumab and Cobimetinib in Treating Patients With Metastatic, Recurrent, or Refractory Non-small Cell Lung CancerNCT03600701 · 2018-11-29
ACTIVE_NOT_RECRUITINGAtezolizumab and Cobimetinib or Idasanutlin in Participants With Stage IV or Unresectable Recurrent Estrogen Receptor Positive Breast CancerNCT03566485 · 2018-07-10
TERMINATEDA Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell Lung Cancer (Morpheus- Non-Small Cell Lung Cancer)NCT03337698 · 2017-12-27
TERMINATEDPre-operative Immunotherapy Combination Strategies in Breast CancerNCT03395899 · 2017-12-21
COMPLETEDA Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC)NCT03178552 · 2017-09-22
ACTIVE_NOT_RECRUITINGA Phase IB/II Study of Alectinib Combined With Cobimetinib in Advanced ALK-Rearranged (ALK+) NSCLCNCT03202940 · 2017-09-14
ACTIVE_NOT_RECRUITINGAtezolizumab, Cobimetinib, and Eribulin in Treating Patients With Chemotherapy Resistant Metastatic Inflammatory Breast CancerNCT03202316 · 2017-08-11
ACTIVE_NOT_RECRUITINGA Study of the Safety, Tolerability, and Effects of Cobimetinib and GDC-0994 in Patients With Locally Advanced or Metastatic Solid TumorsNCT02457793 · 2015-06-16
COMPLETEDA Study of Cobimetinib Plus Paclitaxel, Cobimetinib Plus Atezolizumab Plus Paclitaxel, or Cobimetinib Plus Atezolizumab Plus Nab-Paclitaxel as Initial Treatment for Participants With Triple-Negative Breast Cancer That Has SpreadNCT02322814 · 2015-03-12
TERMINATEDConditions being studied
Breast Cancer3Non-small Cell Lung Cancer3Anatomic Stage IV Breast Cancer AJCC v82Carcinoma, Non-Small-Cell Lung2Erdheim-Chester Disease2Stage II Pancreatic Cancer AJCC v82Stage III Pancreatic Cancer AJCC v82Stage IV Pancreatic Cancer AJCC v82Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive1Advanced Breast Carcinoma1Advanced Malignant Solid Neoplasm1Advanced Ovarian Carcinoma1Advanced Pancreatic Carcinoma1Advanced Prostate Carcinoma1Advanced Sarcoma1Advanced Solid Tumor1Anatomic Stage III Breast Cancer AJCC v81Anemia1Ann Arbor Stage III Hodgkin Lymphoma1Ann Arbor Stage III Non-Hodgkin Lymphoma1
Research locations
New YorkNew York, United States7BostonMassachusetts, United States5NashvilleTennessee, United States5HoustonTexas, United States4San FranciscoCalifornia, United States4SeoulSouth Korea4AuroraColorado, United States3ChicagoIllinois, United States3ColumbusOhio, United States3DetroitMichigan, United States3LebanonNew Hampshire, United States3LondonUnited Kingdom3
Leading sponsors
Hoffmann-La Roche3Genentech, Inc.2OHSU Knight Cancer Institute2ABM Therapeutics Corporation1Cancer Research UK1Carl Allen1Fondazione per la Medicina Personalizzata1M.D. Anderson Cancer Center1Massachusetts General Hospital1National Cancer Institute (NCI)1Queen Mary University of London1Revolution Medicines, Inc.1Vanderbilt-Ingram Cancer Center1
Drug identity and terminology: RxNorm. Trial relationships: ClinicalTrials.gov.