Clinical trial
SMMART Adaptive Clinical Treatment (ACT) Trial
NCT05238831
Study timeline
Study start (estimated)2023-01-30Date precision: day
Registry last updated2024-01-23
Observed by CureCurrent2026-10-07
Recorded dates are source observations, not predictions. Missing milestones are not estimated.
Conditions
Advanced Breast Carcinomaunresolved
Advanced Malignant Solid Neoplasmunresolved
Advanced Ovarian Carcinomaunresolved
Advanced Pancreatic Carcinomaunresolved
Advanced Prostate Carcinomaunresolved
Advanced Sarcomaunresolved
Anatomic Stage III Breast Cancer AJCC v8unresolved
Anatomic Stage IV Breast Cancer AJCC v8unresolved
Recurrent Adult Soft Tissue Sarcomaunresolved
Recurrent Breast Carcinomaunresolved
Recurrent Ovarian Carcinomaunresolved
Recurrent Prostate Carcinomaunresolved
Stage II Pancreatic Cancer AJCC v8unresolved
Stage III Ovarian Cancer AJCC v8unresolved
Stage III Pancreatic Cancer AJCC v8unresolved
Stage IV Ovarian Cancer AJCC v8unresolved
Stage IV Pancreatic Cancer AJCC v8unresolved
Interventions
AlectinibDRUG · verified · RxNorm: alectinib
AlpelisibDRUG · verified · RxNorm: alpelisib
AnastrozoleDRUG · verified · RxNorm: anastrozole
AtezolizumabBIOLOGICAL
BevacizumabBIOLOGICAL
BiopsyPROCEDURE
Biospecimen CollectionPROCEDURE
CapecitabineDRUG · verified · RxNorm: capecitabine
CarboplatinDRUG · verified · RxNorm: carboplatin
CobimetinibDRUG · verified · RxNorm: cobimetinib
EntrectinibDRUG · verified · RxNorm: entrectinib
EribulinDRUG · verified · RxNorm: eribulin
FulvestrantDRUG · verified · RxNorm: fulvestrant
IrinotecanDRUG · verified · RxNorm: irinotecan
LetrozoleDRUG · verified · RxNorm: letrozole
Nab-paclitaxelDRUG
NiraparibDRUG · verified · RxNorm: niraparib
OlaparibDRUG · verified · RxNorm: olaparib
PaclitaxelDRUG · verified · RxNorm: paclitaxel
PalbociclibDRUG · verified · RxNorm: palbociclib
PertuzumabBIOLOGICAL
TrastuzumabBIOLOGICAL
Trastuzumab EmtansineBIOLOGICAL
VemurafenibDRUG · verified · RxNorm: vemurafenib
VinorelbineDRUG · verified · RxNorm: vinorelbine
VismodegibDRUG · verified · RxNorm: vismodegib
Sponsors & collaborators
OHSU Knight Cancer Institutelead sponsor
Genentech, Inc.collaborator
Oregon Health and Science Universitycollaborator
Registry source
Open the source record to verify current eligibility, contacts, locations and registry updates.
Open NCT05238831 on ClinicalTrials.gov ↗Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.