Intervention

Metformin

ClinicalTrials.gov intervention label

Clinical trials700

Recruiting38

Common conditions25

Lead sponsors shown15

Clinical trials

60 shown

Anti-Diabetic Drug, Exercise and Healthy Diet for Knee Osteoarthritis With Overweight/ObesityNCT07065591 · 2026-08-30

Metformin as Adjunct Therapy in Depression-obesity Comorbidity: Clinical and Genetic EvaluationNCT07654179 · 2026-06-17

Comparison of Metformin Versus Glyburide for Blood Sugar Control in Women With Gestational DiabetesNCT07802561 · 2026-04-18

The Effect of Empagliflozin and Metformin on Oxidative Capacity and Microvascular Reactivity of Skeletal Muscle in Patients With Type 2 Diabetes MellitusNCT07771010 · 2026-04-16

Metformin in Parkinson DiseaseNCT07229651 · 2025-11-10

Glycemic Variability of Combination Therapies in T2DMNCT07442006 · 2025-10-29

A Drug-Drug Interaction Study of HDM1002 and Metformin, Empagliflozin, Midazolam, Valsartan, and WarfarinNCT07331389 · 2025-09-24

Effect of Metformin Use on Weight Loss in Obese, Non-diabetic People (MOWRI)NCT07297290 · 2025-07-23

Efficacy and Safety of Add-On Therapy With Empagliflozin in Patients With Type 2 Diabetes on a Background of Alogliptin and MetforminNCT07093476 · 2025-07-18

Anti-atherosclerotic Efficacy of Selected Antidiabetic Drugs in Patients With Coronary Artery Disease and Pre-diabetesNCT07254572 · 2025-07-10

Metformin Alleviates Abnormal Glucose Metabolism Induced by Statins in Schizophrenia PatientsNCT07045142 · 2025-07-01

A Phase IV Clinical Trial to Compare the Efficacy and Safety of Metformin+Sodium-Glucose Cotransporter 2 Inhibitor(SGLT2-i)+Thiazolidinedione (TZD) in Patients With Type 2 DiabetesNCT06972732 · 2025-06-11

Semaglutide and Tirzepatide for Genetic Aging Delay in Adults With ObesityNCT07293325 · 2025-06-02

Metformin as a Neuroprotective Therapy for GlaucomaNCT05426044 · 2025-06-01

Liraglutide Treatment in Obese Infertile PCOS WomenNCT06742710 · 2025-05-22

Metformin in Post Chronic Pancreatitis Diabetes MellitusNCT06937294 · 2025-04-28

Efficacy and Safety of Henagliflozin Proline and Metformin Hydrochloride Extended-release Tablets (Ⅰ) Versus Metformin Tablets in Patients With New-onset Type 2 Diabetes: a Multicenter, Randomized Controlled StudyNCT06888050 · 2025-04-11

Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV- Individuals With a History of Injection Drug UseNCT06829238 · 2025-04-07

Efficacy and Safety of the Met+SGLT-2i+GLP-1RA in Patients With Type 2 Diabetes With Poor Glycemic ControlNCT07244003 · 2025-03-29

Cannabis Potency Effects on Brain White Matter in Early Phase PsychosisNCT07001878 · 2025-03-18

Effects of Metformin on Hepatic Venous Pressure Gradient in Patients With Cirrhosis and Portal HypertensionNCT06687265 · 2025-03-10

Prevention of Progression of Prediabetes, Obesity and CV RiskNCT06446531 · 2024-09-11

DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational DiabetesNCT06445946 · 2024-08-01

Precision Dosing of Metformin in Youth With T2DNCT06120881 · 2024-04-25

A Feasibility Study Evaluating a Role for Maintenance Therapy in Patients With Biochemically Progressive Castration Sensitive Prostate Cancer on Intermittent Androgen Deprivation TherapyNCT06044025 · 2024-04-11

The EMPA-FIT StudyNCT06846411 · 2024-01-01

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid TumorsNCT05768139 · 2023-04-17

Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual DisabilityNCT05744479 · 2023-02-28

SGLT2 Inhibitors As First Line Therapy to Prevent Renal Decline in Type 2 DiabetesNCT05345327 · 2023-01-01

Pragmatic Trial of Metformin for Glucose Intolerance or Increased BMI in Prostate Cancer PatientsNCT05515978 · 2022-10-10

The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin ActionNCT05414409 · 2022-09-30

Effect of Tofogliflozin on UACR Compared to Metformin Hydrochloride in Diabetic Kidney Disease (TRUTH-DKD)NCT05469659 · 2021-09-22

Extending Time Without Diabetes After Bariatric Surgery: a Trial Comparing the Metformin Addition or Not to Standard CareNCT04581447 · 2021-01-07

A Phase I Double Blind Study of Metformin Acting on Endogenous Neural Progenitor Cells in Children and Young Adults With Multiple SclerosisNCT04121468 · 2020-02-24

Impact of P53 and SIRT1 in Type 2 DiabetesNCT03925714 · 2019-04-01

Impact of Metformin on Immuno-virologic Parameters in HIVNCT04500678 · 2019-02-01

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast CancerNCT03424005 · 2018-03-30

Pre-diabetes in Subject With Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT)NCT02969798 · 2014-01-01

Evaluation of Superiority of Valsartan+Celecoxib+Metformin Over Metformin Alone in Type 2 Diabetes PatientsNCT03686657 · 2026-12-10

Cardioprotective Effect of Empagliflozin in Breast Cancer PatientsNCT07815808 · 2026-10-01

NOT_YET_RECRUITING

Metformin-Dapagliflozin Effects on IGF-1 in Male T2DM With MASLDNCT07778719 · 2026-10-01

NOT_YET_RECRUITING

Dapagliflozin Versus Metformin for the Management of Antipsychotic-Induced Weight Gain: A Pragmatic Pilot Randomized Controlled TrialNCT07342764 · 2026-09-01

NOT_YET_RECRUITING

Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD ExacerbationsNCT07275359 · 2026-09-01

NOT_YET_RECRUITING

Efficacy and Safety of Hebenrun in Patients With Type 2 DiabetesNCT07768280 · 2026-09-01

NOT_YET_RECRUITING

Inositol and Metformin Administration in Mediterranean Diet and Low-Carbohydrate Diets in Women With PCOSNCT07770711 · 2026-08-20

NOT_YET_RECRUITING

Effects of GLP-1RAs on Fertility Outcomes in Obese Women With PCOSNCT07687667 · 2026-07-01

NOT_YET_RECRUITING

Clinical Trials to Evaluate Metformin to Treat Depression in People Living With HIVNCT07007221 · 2026-07-01

Metformin Combined With Secukinumab for Moderate-to-Severe Plaque Psoriasis in Overweight or Obese Chinese PatientsNCT07485764 · 2026-06-01

NOT_YET_RECRUITING

Effects of Cofrogliptin on Beta-Cell Function in LADA PatientsNCT07460336 · 2026-05-15

NOT_YET_RECRUITING

Hypertension Treatment in Nigeria: Hypertension Diabetes Integration Study- Formative Aim 3NCT07589387 · 2026-05-01

NOT_YET_RECRUITING

Influence of HDM1005 on Gastric Emptying and Pharmacokinetics of Metformin, Atorvastatin, Warfarin, and DigoxinNCT07502001 · 2026-04-08

NOT_YET_RECRUITING

Regimen Transition After Short-Term Intensive Insulin Therapy in Type 2 DiabetesNCT07173712 · 2026-03-15

NOT_YET_RECRUITING

A Study to Evaluate VH4524184 Tablet Absorption, Effects of Food, and Interactions With Other Drugs in Healthy AdultsNCT07066722 · 2025-07-07

Comparative Efficacy of Metformin and Berberine Among TCF7L2 (rs7903146) TT vs. CC Genotype Carriers With Type 2 DiabetesNCT06911983 · 2025-07-01

NOT_YET_RECRUITING

Empagliflozin Versus Non-SGLT2 Oral Drugs for Blood Pressure in Type 2 DiabetesNCT07541456 · 2025-06-09

Metformin Versus Standard of Care Treatment in Pregnant Women With PrediabetesNCT04523363 · 2025-06-01

Comparative Clinical and Biochemical Study Evaluating the Effectiveness of Metformin Versus Febuxostat on Gouty Obese Non-Diabetic PatientsNCT06995339 · 2025-05-30

Impact of Pharmacogenetic-Guided Treatment on Type 2 Diabetes.NCT06851962 · 2025-05-26

Antidiabetic Medications and Risk of CancerNCT07628556 · 2025-03-15

Semaglutide vs Metformin in Polycystic Ovary Syndrome (PCOS)NCT05646199 · 2025-03-01

Common conditions

Leading sponsors

Merck Sharp & Dohme LLC44 Sanofi38 AstraZeneca23 Eli Lilly and Company14 Novartis Pharmaceuticals13 Takeda13 GlaxoSmithKline9 Boehringer Ingelheim7 Janssen Research & Development, LLC7 National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)7 Ain Shams University5 Hoffmann-La Roche5 M.D. Anderson Cancer Center5 Massachusetts General Hospital5 RenJi Hospital5

Trial status mix

COMPLETED448

UNKNOWN93

TERMINATED60

RECRUITING38

WITHDRAWN28

ACTIVE_NOT_RECRUITING16

NOT_YET_RECRUITING15

ENROLLING_BY_INVITATION1

SUSPENDED1

Phase mix

PHASE3203

PHASE4187

PHASE2174

NA77

PHASE170

EARLY_PHASE110

Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.